Short-term oral exposure to white wine transiently lowers serum free fatty acids

M.M. Joosten, C. de Graaf, A. Rietman, R.F. Witkamp, H.F.J. Hendriks

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

In humans little is known as to whether oral sensory stimulation with alcohol elicits cephalic phase responses. This study sought to determine whether oral alcohol exposure, in the form of white wine, provokes cephalic phase responses in normal-weight and overweight women. In a semi-randomized, crossover trial, eleven normal-weight and eleven overweight women sham-fed, after an overnight fast under three separate conditions 4 weeks apart, cake (750 kJ), 25 cL white wine (750 kJ; 26 g alcohol) and 25 cL water. Blood was drawn prior to and for 30 min after two 3-min episodes of modified sham-feeding (MSF). Blood samples were analyzed for free fatty acid (FFA), triglyceride, glucose, pancreatic polypeptide (PP), insulin and alcohol concentrations. Incremental area under the curves (IAUC) of FFA concentrations differed significantly between the three treatments but not between BMI categories. After MSF with wine, FFA concentrations dropped to a minimum of 77 ± 3% of baseline concentrations at t = 12 ± 2 min after baseline and returned to baseline after 30 min, whereas after MSF with cake and water, FFA concentrations gradually increased. In conclusion, short-term oral white wine exposure substantially and temporarily decreases FFA concentrations suggesting a cephalic phase response of alcohol. This effect occurred regardless of BMI.
Original languageEnglish
Pages (from-to)124-129
JournalAppetite
Volume55
Issue number1
DOIs
Publication statusPublished - 2010

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Wine
Nonesterified Fatty Acids
Alcohols
Serum
Head
Pancreatic Polypeptide
Weights and Measures
Water
Cross-Over Studies
Area Under Curve
Triglycerides
Insulin
Glucose

Keywords

  • moderate alcohol-consumption
  • postprandial lipid-metabolism
  • phase insulin-release
  • cephalic phase
  • mixed meal
  • substrate mobilization
  • sensory stimulation
  • glucose-metabolism
  • food-intake
  • humans

Cite this

Joosten, M.M. ; de Graaf, C. ; Rietman, A. ; Witkamp, R.F. ; Hendriks, H.F.J. / Short-term oral exposure to white wine transiently lowers serum free fatty acids. In: Appetite. 2010 ; Vol. 55, No. 1. pp. 124-129.
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abstract = "In humans little is known as to whether oral sensory stimulation with alcohol elicits cephalic phase responses. This study sought to determine whether oral alcohol exposure, in the form of white wine, provokes cephalic phase responses in normal-weight and overweight women. In a semi-randomized, crossover trial, eleven normal-weight and eleven overweight women sham-fed, after an overnight fast under three separate conditions 4 weeks apart, cake (750 kJ), 25 cL white wine (750 kJ; 26 g alcohol) and 25 cL water. Blood was drawn prior to and for 30 min after two 3-min episodes of modified sham-feeding (MSF). Blood samples were analyzed for free fatty acid (FFA), triglyceride, glucose, pancreatic polypeptide (PP), insulin and alcohol concentrations. Incremental area under the curves (IAUC) of FFA concentrations differed significantly between the three treatments but not between BMI categories. After MSF with wine, FFA concentrations dropped to a minimum of 77 ± 3{\%} of baseline concentrations at t = 12 ± 2 min after baseline and returned to baseline after 30 min, whereas after MSF with cake and water, FFA concentrations gradually increased. In conclusion, short-term oral white wine exposure substantially and temporarily decreases FFA concentrations suggesting a cephalic phase response of alcohol. This effect occurred regardless of BMI.",
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Short-term oral exposure to white wine transiently lowers serum free fatty acids. / Joosten, M.M.; de Graaf, C.; Rietman, A.; Witkamp, R.F.; Hendriks, H.F.J.

In: Appetite, Vol. 55, No. 1, 2010, p. 124-129.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Short-term oral exposure to white wine transiently lowers serum free fatty acids

AU - Joosten, M.M.

AU - de Graaf, C.

AU - Rietman, A.

AU - Witkamp, R.F.

AU - Hendriks, H.F.J.

PY - 2010

Y1 - 2010

N2 - In humans little is known as to whether oral sensory stimulation with alcohol elicits cephalic phase responses. This study sought to determine whether oral alcohol exposure, in the form of white wine, provokes cephalic phase responses in normal-weight and overweight women. In a semi-randomized, crossover trial, eleven normal-weight and eleven overweight women sham-fed, after an overnight fast under three separate conditions 4 weeks apart, cake (750 kJ), 25 cL white wine (750 kJ; 26 g alcohol) and 25 cL water. Blood was drawn prior to and for 30 min after two 3-min episodes of modified sham-feeding (MSF). Blood samples were analyzed for free fatty acid (FFA), triglyceride, glucose, pancreatic polypeptide (PP), insulin and alcohol concentrations. Incremental area under the curves (IAUC) of FFA concentrations differed significantly between the three treatments but not between BMI categories. After MSF with wine, FFA concentrations dropped to a minimum of 77 ± 3% of baseline concentrations at t = 12 ± 2 min after baseline and returned to baseline after 30 min, whereas after MSF with cake and water, FFA concentrations gradually increased. In conclusion, short-term oral white wine exposure substantially and temporarily decreases FFA concentrations suggesting a cephalic phase response of alcohol. This effect occurred regardless of BMI.

AB - In humans little is known as to whether oral sensory stimulation with alcohol elicits cephalic phase responses. This study sought to determine whether oral alcohol exposure, in the form of white wine, provokes cephalic phase responses in normal-weight and overweight women. In a semi-randomized, crossover trial, eleven normal-weight and eleven overweight women sham-fed, after an overnight fast under three separate conditions 4 weeks apart, cake (750 kJ), 25 cL white wine (750 kJ; 26 g alcohol) and 25 cL water. Blood was drawn prior to and for 30 min after two 3-min episodes of modified sham-feeding (MSF). Blood samples were analyzed for free fatty acid (FFA), triglyceride, glucose, pancreatic polypeptide (PP), insulin and alcohol concentrations. Incremental area under the curves (IAUC) of FFA concentrations differed significantly between the three treatments but not between BMI categories. After MSF with wine, FFA concentrations dropped to a minimum of 77 ± 3% of baseline concentrations at t = 12 ± 2 min after baseline and returned to baseline after 30 min, whereas after MSF with cake and water, FFA concentrations gradually increased. In conclusion, short-term oral white wine exposure substantially and temporarily decreases FFA concentrations suggesting a cephalic phase response of alcohol. This effect occurred regardless of BMI.

KW - moderate alcohol-consumption

KW - postprandial lipid-metabolism

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KW - mixed meal

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KW - humans

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