Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

M.J.W. Hanssen, J. Hoeks, B. Brans, M.V. Boekschoten, A.H. Kersten

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191 Citations (Scopus)


Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
Original languageEnglish
Pages (from-to)863-865
JournalNature Medicine
Issue number8
Publication statusPublished - 2015


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