Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
|Publication status||Published - 2015|
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Cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.
Hanssen, M. J. (Creator), Hoeks, J. (Creator), Boekschoten, M. (Creator), Kersten, S. (Creator), Marken Lichtenbelt, W. D. (Creator) & Schrauwen, P. (Creator), Wageningen University, 5 Jul 2015