Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

M.J.W. Hanssen; J. Hoeks; B. Brans; M.V. Boekschoten; A.H. Kersten

doi:10.1038/nm.3891

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

M.J.W. Hanssen, J. Hoeks, B. Brans, M.V. Boekschoten, A.H. Kersten

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.

Original language	English
Pages (from-to)	863-865
Journal	Nature Medicine
Volume	21
Issue number	8
DOIs	https://doi.org/10.1038/nm.3891
Publication status	Published - 2015

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10.1038/nm.3891

Cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.
Hanssen, M. J. (Creator), Hoeks, J. (Creator), Boekschoten, M. (Creator), Kersten, S. (Creator), Marken Lichtenbelt, W. D. (Creator) & Schrauwen, P. (Creator), Wageningen University, 5 Jul 2015
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67297
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Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Abstract

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Cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.

Cite this