Short communication: Genome-wide scan for bovine milk-fat composition. II. Quantitative trait loci for long-chain fatty acids

A. Schennink, W.M. Stoop, M.H.P.W. Visker, J.J. van der Poel, H. Bovenhuis, J.A.M. van Arendonk

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Abstract

We present the results of a genome-wide scan to identify quantitative trait loci (QTL) that contribute to genetic variation in long-chain milk fatty acids. Milk-fat composition phenotypes were available on 1,905 Dutch Holstein-Friesian cows. A total of 849 cows and their 7 sires were genotyped for 1,341 single nucleotide polymorphisms across all Bos taurus autosomes (BTA). We detected significant QTL on BTA14, BTA15, and BTA16: for C18:1 cis-9, C18:1 cis-12, C18:2 cis-9,12, CLA cis-9,trans-11, C18:3 cis-9,12,15, the C18 index, the total index, total saturated fatty acids, total unsaturated fatty acids (UFA), and the ratio of saturated fatty acids:unsaturated fatty acids on BTA14; for C18:1 trans fatty acids on BTA15; and for the C18 and CLA indices on BTA16. The QTL explained 3 to 19% of the phenotypic variance. Suggestive QTL were found on 16 other chromosomes. The diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism on BTA14, which is known to influence fatty acid composition, most likely explains the QTL that was detected on BTA14
Original languageEnglish
Pages (from-to)4676-4682
JournalJournal of Dairy Science
Volume92
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • dairy-cattle
  • genetic-parameters
  • f-2 population
  • rat-liver
  • fish-oil
  • dgat1
  • polymorphism
  • trans
  • cows
  • qtl

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