Shooting the messenger

RNA-targetting CRISPR-Cas systems

Yifan Zhu, Sanne E. Klompe, Marnix Vlot, John van der Oost, Raymond H.J. Staals*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.

Original languageEnglish
Article numberBSR20170788
JournalBioscience Reports
Volume38
Issue number3
DOIs
Publication statusPublished - 21 Jun 2018

Fingerprint

Clustered Regularly Interspaced Short Palindromic Repeats
Genes
Messenger RNA
RNA
Deoxyribonucleases
Immune system
Biological systems
RNA Interference
Immune System
Genome
DNA
Research

Cite this

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title = "Shooting the messenger: RNA-targetting CRISPR-Cas systems",
abstract = "Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.",
author = "Yifan Zhu and Klompe, {Sanne E.} and Marnix Vlot and {van der Oost}, John and Staals, {Raymond H.J.}",
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language = "English",
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Shooting the messenger : RNA-targetting CRISPR-Cas systems. / Zhu, Yifan; Klompe, Sanne E.; Vlot, Marnix; van der Oost, John; Staals, Raymond H.J.

In: Bioscience Reports, Vol. 38, No. 3, BSR20170788, 21.06.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Shooting the messenger

T2 - RNA-targetting CRISPR-Cas systems

AU - Zhu, Yifan

AU - Klompe, Sanne E.

AU - Vlot, Marnix

AU - van der Oost, John

AU - Staals, Raymond H.J.

PY - 2018/6/21

Y1 - 2018/6/21

N2 - Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.

AB - Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.

U2 - 10.1042/BSR20170788

DO - 10.1042/BSR20170788

M3 - Article

VL - 38

JO - Bioscience Reports

JF - Bioscience Reports

SN - 0144-8463

IS - 3

M1 - BSR20170788

ER -