Shooting the messenger: RNA-targetting CRISPR-Cas systems

Yifan Zhu; Sanne E. Klompe; Marnix Vlot; John van der Oost; Raymond H.J. Staals

doi:10.1042/BSR20170788

Shooting the messenger: RNA-targetting CRISPR-Cas systems

Yifan Zhu, Sanne E. Klompe, Marnix Vlot, John van der Oost, Raymond H.J. Staals^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.

Original language	English
Article number	BSR20170788
Journal	Bioscience Reports
Volume	38
Issue number	3
DOIs	https://doi.org/10.1042/BSR20170788
Publication status	Published - 21 Jun 2018

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10.1042/BSR20170788Licence: CC BY

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Shooting the messenger: RNA-targetting CRISPR-Cas systems

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