Shooting the messenger: RNA-targetting CRISPR-Cas systems

Yifan Zhu, Sanne E. Klompe, Marnix Vlot, John van der Oost, Raymond H.J. Staals*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)


Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.

Original languageEnglish
Article numberBSR20170788
JournalBioscience Reports
Issue number3
Publication statusPublished - 21 Jun 2018


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