TY - JOUR
T1 - Serum glutamine synthetase has no value as a diagnostic biomarker for alzheimer's disease
AU - Vermeiren, Yannick
AU - Bastard, Nathalie Le
AU - Clark, Christopher M.
AU - Engelborghs, Sebastiaan
AU - De Deyn, Peter P.
PY - 2011/10
Y1 - 2011/10
N2 - In order to test whether serum glutamine synthetase (GS) is of potential diagnostic value for Alzheimer's disease (AD), we set up a study to compare serum GS concentrations between AD patients and control subjects. The study population (n = 165) consisted of AD patients (n = 94) and age-matched (n = 41) and ageunmatched (n = 30) control subjects. Serum GS analysis was performed by means of ELISA. No significant differences in serum GS levels were found between the ADgroup and age-matched controls. Age correlated positively with serum GS concentrations in AD patients and control subjects. This study suggests that serum GS levels have no diagnostic value for AD.
AB - In order to test whether serum glutamine synthetase (GS) is of potential diagnostic value for Alzheimer's disease (AD), we set up a study to compare serum GS concentrations between AD patients and control subjects. The study population (n = 165) consisted of AD patients (n = 94) and age-matched (n = 41) and ageunmatched (n = 30) control subjects. Serum GS analysis was performed by means of ELISA. No significant differences in serum GS levels were found between the ADgroup and age-matched controls. Age correlated positively with serum GS concentrations in AD patients and control subjects. This study suggests that serum GS levels have no diagnostic value for AD.
KW - Alzheimer's disease
KW - Biomarkers
KW - Glutamine synthetase
KW - Serum
U2 - 10.1007/s11064-011-0504-4
DO - 10.1007/s11064-011-0504-4
M3 - Article
C2 - 21597934
AN - SCOPUS:80555150813
SN - 0364-3190
VL - 36
SP - 1858
EP - 1862
JO - Neurochemical Research
JF - Neurochemical Research
IS - 10
ER -