Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly

E.M. Brouwer, O. Nieuwerth-van de Rest, C.A.B. Tieland, N.L. van der Zwaluw, W.T. Steegenga, J.J. Adam, L.J.C. van Loon, E.J.M. Feskens, C.P.G.M. de Groot

Research output: Chapter in Book/Report/Conference proceedingAbstract


Background Vitamin D deficiency is a common phenomenon all over the globe. Although vitamin D is best known for its role in calcium metabolism, recent studies suggest that it may also be favourable for cognitive processes. The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25(OH)D) and vitamin D intake with various domains of cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were mediated or modified by fasting plasma glucose (FPG) levels. Methods This cross-sectional study was conducted using data of 127 pre-frail and frail Dutch elderly. Associations of vitamin D with domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with global cognitive performance was explored by Poisson regression. Results Participants were on average 79 years old and had a mean MMSE score of 27.7±2.2. Serum 25(OH)D was positively associated with cognitive executive function (ß 0.007, P=0.01) and tended to be associated with information processing speed (ß 0.006, P=0.06), after adjustment for age, sex, BMI, educational level, alcohol intake, smoking, physical activity level and season of blood sampling. Glucose did neither modify nor mediate the association between serum 25(OH)D and domain specific cognitive performance. There was no association between vitamin D intake and cognitive performance. Conclusios This cross-sectional study suggests an association of serum 25(OH)D with domain specific cognitive performance, more specifically executive functioning. Whether this association is causal is yet to be demonstrated.
Original languageEnglish
Title of host publicationAlzheimer’s Association International Conference
Publication statusPublished - 2013
EventAlzheimer’s Association International Conference 2013, Boston, Massachusetts, USA -
Duration: 13 Jul 201318 Jul 2013


ConferenceAlzheimer’s Association International Conference 2013, Boston, Massachusetts, USA


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