Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression

E.M. Brouwer, O. Nieuwerth-van de Rest, C.A.B. Tieland, N.L. van der Zwaluw, W.T. Steegenga, J.J. Adam, L.J.C. van Loon, E.J.M. Feskens, C.P.G.M. de Groot

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)

Abstract

Objectives: The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH] D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels. Design, Setting, and Participants: Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65 years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria. Measurements: Associations of 25(OH) D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression. Results: No associations were observed for 25(OH) D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH) D was positively associated with executive functioning (beta 0.007, P=.01) and tended to be associated with information-processing speed (beta 0.006, P=.06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression. Conclusion: This cross-sectional study suggests an association of serum 25(OH) D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated. Copyright (C) 2013 - American Medical Directors Association, Inc.
LanguageEnglish
Pages852.e9-852.e17
JournalJournal of the American Medical Directors Association
Volume14
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Frail Elderly
Executive Function
Cognition
Cross-Sectional Studies
Fasting
Depression
Vitamin D
Glucose
Serum
Automatic Data Processing
Insulin Resistance
Homeostasis
Insulin
25-hydroxyvitamin D
Regression Analysis

Keywords

  • randomized controlled-trial
  • vitamin-d supplementation
  • placebo-controlled trial
  • parathyroid-hormone
  • insulin-resistance
  • double-blind
  • older women
  • risk-factors
  • us adults
  • population

Cite this

@article{9626ebceb41a43f4940b2c103a32d082,
title = "Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression",
abstract = "Objectives: The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH] D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels. Design, Setting, and Participants: Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65 years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria. Measurements: Associations of 25(OH) D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression. Results: No associations were observed for 25(OH) D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH) D was positively associated with executive functioning (beta 0.007, P=.01) and tended to be associated with information-processing speed (beta 0.006, P=.06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression. Conclusion: This cross-sectional study suggests an association of serum 25(OH) D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated. Copyright (C) 2013 - American Medical Directors Association, Inc.",
keywords = "randomized controlled-trial, vitamin-d supplementation, placebo-controlled trial, parathyroid-hormone, insulin-resistance, double-blind, older women, risk-factors, us adults, population",
author = "E.M. Brouwer and {Nieuwerth-van de Rest}, O. and C.A.B. Tieland and {van der Zwaluw}, N.L. and W.T. Steegenga and J.J. Adam and {van Loon}, L.J.C. and E.J.M. Feskens and {de Groot}, C.P.G.M.",
year = "2013",
doi = "10.1016/j.jamda.2013.06.010",
language = "English",
volume = "14",
pages = "852.e9--852.e17",
journal = "Journal of the American Medical Directors Association",
issn = "1525-8610",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression

AU - Brouwer, E.M.

AU - Nieuwerth-van de Rest, O.

AU - Tieland, C.A.B.

AU - van der Zwaluw, N.L.

AU - Steegenga, W.T.

AU - Adam, J.J.

AU - van Loon, L.J.C.

AU - Feskens, E.J.M.

AU - de Groot, C.P.G.M.

PY - 2013

Y1 - 2013

N2 - Objectives: The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH] D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels. Design, Setting, and Participants: Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65 years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria. Measurements: Associations of 25(OH) D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression. Results: No associations were observed for 25(OH) D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH) D was positively associated with executive functioning (beta 0.007, P=.01) and tended to be associated with information-processing speed (beta 0.006, P=.06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression. Conclusion: This cross-sectional study suggests an association of serum 25(OH) D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated. Copyright (C) 2013 - American Medical Directors Association, Inc.

AB - Objectives: The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH] D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels. Design, Setting, and Participants: Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65 years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria. Measurements: Associations of 25(OH) D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression. Results: No associations were observed for 25(OH) D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH) D was positively associated with executive functioning (beta 0.007, P=.01) and tended to be associated with information-processing speed (beta 0.006, P=.06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression. Conclusion: This cross-sectional study suggests an association of serum 25(OH) D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated. Copyright (C) 2013 - American Medical Directors Association, Inc.

KW - randomized controlled-trial

KW - vitamin-d supplementation

KW - placebo-controlled trial

KW - parathyroid-hormone

KW - insulin-resistance

KW - double-blind

KW - older women

KW - risk-factors

KW - us adults

KW - population

U2 - 10.1016/j.jamda.2013.06.010

DO - 10.1016/j.jamda.2013.06.010

M3 - Article

VL - 14

SP - 852.e9-852.e17

JO - Journal of the American Medical Directors Association

T2 - Journal of the American Medical Directors Association

JF - Journal of the American Medical Directors Association

SN - 1525-8610

IS - 1

ER -