Serum 25-hydroxy-vitamin D3 concentrations increase during tuberculosis treatment in Tanzania

A. Tostmann, J.P.M. Wielders, G.S. Kibiki, H. Verhoef, M.J. Boeree, A.J.A.M. van der Ven

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)

Abstract

SETTING: Vitamin D deficiency is associated with susceptibility to active tuberculosis (TB) in many settings. In vitro studies and studies on human volunteers showed that two of the first-line anti-tuberculosis drugs, isoniazid and rifampicin, reduce 25-hydroxy vitamin D (25[OH]D) concentrations. OBJECTIVE: To study changes in vitamin D status during treatment of Tanzanian hospitalised patients with pulmonary TB (PTB). DESIGN: We compared serum 25[OH]D concentrations in 81 Tanzanian PTB patients before and after 2 months of treatment. RESULTS: Median serum 25[OH]D concentrations increased from 91 nmol/l at baseline to 101 nmol/l after 2 months of TB treatment (median increase 6.0 nmol/l, IQR -0.7-25.0, P = 0.001). Median serum parathyroid hormone concentrations increased from 1.6 to 2.0 pmol/l (median increase 0.46, IQR -0.2-1.1, P <0.001). CONCLUSION: 25[OH]D serum concentrations increased during the first 2 months of TB treatment in 81 PTB patients in northern Tanzania. Improved dietary intake and increased sunlight exposure may have contributed to the increased 25[OH]D concentrations
Original languageEnglish
Pages (from-to)1147-1152
JournalThe International Journal of Tubercolosis and Lung Disease
Volume14
Issue number9
Publication statusPublished - 2010

Keywords

  • vitamin-d metabolism
  • pulmonary tuberculosis
  • immune regulation
  • human-monocytes
  • d deficiency
  • inhibition
  • rifampicin
  • interferon
  • infection
  • cyp3a4

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