Sensitivity of a point of care tick-test for the development of Lyme borreliosis

H. Sprong, A.D. van Leeuwen, M. Fonville, M. Harms, A.J.H. van Vliet, W. van Pelt, J.A. Ferreira, C.C. van den Wijngaard

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Abstract

Background: A commercially available self-test for the detection of Borrelia burgdorferi sensu lato in ticks was evaluated for its ability to predict erythema migrans formation. Findings: The self-test was performed on 127 Ixodes ricinus from 122 humans that reported tick bites at enrolment and occurrence of symptoms during follow-up. The self-test gave negative results on all the 122 individuals, 14 of whom reported erythema migrans (EM) at follow-up of which 10 were confirmed by their GP. The estimated sensitivity of the self-test for prediction of EM formation is 0% (95% Cl: 0%-28%). Conclusions: This self-test is not suitable for reducing the number needed to treat in a post-exposure prophylaxis setting as it already missed all the obvious early Lyme borreliosis cases.
Original languageEnglish
Article number338
JournalParasites & Vectors
Volume6
DOIs
Publication statusPublished - 2013

Keywords

  • borne diseases
  • ixodes-ricinus
  • netherlands
  • europe
  • bite

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    Sprong, H., van Leeuwen, A. D., Fonville, M., Harms, M., van Vliet, A. J. H., van Pelt, W., Ferreira, J. A., & van den Wijngaard, C. C. (2013). Sensitivity of a point of care tick-test for the development of Lyme borreliosis. Parasites & Vectors, 6, [338]. https://doi.org/10.1186/1756-3305-6-338