Selectivity in the sample preparation for the analysis of drug residues in products of animal origin using LC-MS

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Abstract

Sample preparation is critical in relation to analysis time, sample throughput and therefore analysis costs. Due to recent advances in liquid chromatography-mass spectrometry (LC-MS) instrumentation, the detection of many compounds within one run became possible, and methods for the simultaneous analysis of different compound groups were developed. To be able to analyze compounds with different physical and chemical properties simultaneously, generic, non-selective sample-preparation procedures are applied. The most frequently reported generic sample-preparation methods are a solvent extraction only, solid-phase extraction and a Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) approach. These multi-analyte methods – sometimes including more than 150 different compounds – are of much interest for analytical laboratories due to their reduction in costs. A clear drawback of generic sample-preparation procedures is the occurrence of abundant matrix effects, which compromise detection limits, quantitative aspects, method selectivity and maintenance frequency. In contrast to the trend towards non-selective sample preparation, an opposite trend towards more selective sample-preparation methods is expected to be able to confirm the identity of compounds unambiguously (e.g., stereoisomers). This review gives an overview of generic sample-preparation procedures in the analysis of veterinary drug residues in products of animal origin using LC-MS as the detection technique and an outlook towards expected future trends.
Original languageEnglish
Pages (from-to)229-239
Number of pages11
JournalTrAC : Trends in Analytical Chemistry
Volume43
DOIs
Publication statusPublished - 2013

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Drug Residues
Liquid chromatography
Mass spectrometry
Animals
Veterinary Drugs
Stereoisomerism
Solvent extraction
Chemical properties
Costs
Physical properties
Throughput

Keywords

  • tandem mass-spectrometry
  • quantitative trace analysis
  • solid-phase extraction
  • veterinary drugs
  • antibiotic-residues
  • multiclass method
  • environmental-samples
  • multiresidue method
  • screening method
  • food analysis

Cite this

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title = "Selectivity in the sample preparation for the analysis of drug residues in products of animal origin using LC-MS",
abstract = "Sample preparation is critical in relation to analysis time, sample throughput and therefore analysis costs. Due to recent advances in liquid chromatography-mass spectrometry (LC-MS) instrumentation, the detection of many compounds within one run became possible, and methods for the simultaneous analysis of different compound groups were developed. To be able to analyze compounds with different physical and chemical properties simultaneously, generic, non-selective sample-preparation procedures are applied. The most frequently reported generic sample-preparation methods are a solvent extraction only, solid-phase extraction and a Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) approach. These multi-analyte methods – sometimes including more than 150 different compounds – are of much interest for analytical laboratories due to their reduction in costs. A clear drawback of generic sample-preparation procedures is the occurrence of abundant matrix effects, which compromise detection limits, quantitative aspects, method selectivity and maintenance frequency. In contrast to the trend towards non-selective sample preparation, an opposite trend towards more selective sample-preparation methods is expected to be able to confirm the identity of compounds unambiguously (e.g., stereoisomers). This review gives an overview of generic sample-preparation procedures in the analysis of veterinary drug residues in products of animal origin using LC-MS as the detection technique and an outlook towards expected future trends.",
keywords = "tandem mass-spectrometry, quantitative trace analysis, solid-phase extraction, veterinary drugs, antibiotic-residues, multiclass method, environmental-samples, multiresidue method, screening method, food analysis",
author = "B.J.A. Berendsen and A.A.M. Stolker and M.W.F. Nielen",
year = "2013",
doi = "10.1016/j.trac.2012.09.019",
language = "English",
volume = "43",
pages = "229--239",
journal = "TrAC : Trends in Analytical Chemistry",
issn = "0165-9936",
publisher = "Elsevier",

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TY - JOUR

T1 - Selectivity in the sample preparation for the analysis of drug residues in products of animal origin using LC-MS

AU - Berendsen, B.J.A.

AU - Stolker, A.A.M.

AU - Nielen, M.W.F.

PY - 2013

Y1 - 2013

N2 - Sample preparation is critical in relation to analysis time, sample throughput and therefore analysis costs. Due to recent advances in liquid chromatography-mass spectrometry (LC-MS) instrumentation, the detection of many compounds within one run became possible, and methods for the simultaneous analysis of different compound groups were developed. To be able to analyze compounds with different physical and chemical properties simultaneously, generic, non-selective sample-preparation procedures are applied. The most frequently reported generic sample-preparation methods are a solvent extraction only, solid-phase extraction and a Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) approach. These multi-analyte methods – sometimes including more than 150 different compounds – are of much interest for analytical laboratories due to their reduction in costs. A clear drawback of generic sample-preparation procedures is the occurrence of abundant matrix effects, which compromise detection limits, quantitative aspects, method selectivity and maintenance frequency. In contrast to the trend towards non-selective sample preparation, an opposite trend towards more selective sample-preparation methods is expected to be able to confirm the identity of compounds unambiguously (e.g., stereoisomers). This review gives an overview of generic sample-preparation procedures in the analysis of veterinary drug residues in products of animal origin using LC-MS as the detection technique and an outlook towards expected future trends.

AB - Sample preparation is critical in relation to analysis time, sample throughput and therefore analysis costs. Due to recent advances in liquid chromatography-mass spectrometry (LC-MS) instrumentation, the detection of many compounds within one run became possible, and methods for the simultaneous analysis of different compound groups were developed. To be able to analyze compounds with different physical and chemical properties simultaneously, generic, non-selective sample-preparation procedures are applied. The most frequently reported generic sample-preparation methods are a solvent extraction only, solid-phase extraction and a Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) approach. These multi-analyte methods – sometimes including more than 150 different compounds – are of much interest for analytical laboratories due to their reduction in costs. A clear drawback of generic sample-preparation procedures is the occurrence of abundant matrix effects, which compromise detection limits, quantitative aspects, method selectivity and maintenance frequency. In contrast to the trend towards non-selective sample preparation, an opposite trend towards more selective sample-preparation methods is expected to be able to confirm the identity of compounds unambiguously (e.g., stereoisomers). This review gives an overview of generic sample-preparation procedures in the analysis of veterinary drug residues in products of animal origin using LC-MS as the detection technique and an outlook towards expected future trends.

KW - tandem mass-spectrometry

KW - quantitative trace analysis

KW - solid-phase extraction

KW - veterinary drugs

KW - antibiotic-residues

KW - multiclass method

KW - environmental-samples

KW - multiresidue method

KW - screening method

KW - food analysis

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VL - 43

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EP - 239

JO - TrAC : Trends in Analytical Chemistry

JF - TrAC : Trends in Analytical Chemistry

SN - 0165-9936

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