Selective genotyping to detect QTL for multiple traits in outbred populations

H. Bovenhuis, R.J. Spelman

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Abstract

Selective genotyping (i.e., genotyping of individuals that are extreme for a quantitative trait) has been undertaken in many studies but has usually been limited to one trait of interest. This paper outlines the implications of selective genotyping when applied to a daughter design. Formulas are presented that enable unbiased estimation of QTL effects for the selectively genotyped and correlated traits. Formulas were verified using simulation. Further, formulas are presented to enable power calculations to be undertaken for the selectively genotyped trait and correlated traits. These algorithms are demonstrated with a numerical example.
Original languageEnglish
Pages (from-to)173-180
JournalJournal of Dairy Science
Volume83
Issue number1
DOIs
Publication statusPublished - 2000

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