Selection for growth rate and body size have altered the expression profiles of somatotropic axis genes in chickens

Junjing Jia, Irfan Ahmed, Lixian Liu, Yong Liu, Zhiqiang Xu, Xiaohua Duan, Qihua Li, Tengfei Dou, Dahai Gu, Hua Rong, Kun Wang, Zhengtian Li, Mir Zulqarnain Talpur, Ying Huang, Shanrong Wang, Shixiong Yan, Huiquan Tong, Sumei Zhao, Guiping Zhao, Marinus F.W. te Pas*Zhengchang Su, Changrong Ge

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

The growth hormone / insulin-like growth factor-1 (GH/IGF-1) pathway of the somatotropic axis is the major controller for growth rate and body size in vertebrates, but the effect of selection on the expression of GH/IGF-1 somatotropic axis genes and their association with body size and growth performance in farm animals is not fully understood. We analyzed a time series of expression profiles of GH/IGF-1 somatotropic axis genes in two chicken breeds, the Daweishan mini chickens and Wuding chickens, and the commercial Avian broilers hybrid exhibiting markedly different body sizes and growth rates. We found that growth rate and feed conversion efficiency in Daweishan mini chickens were significantly lower than those in Wuding chickens and Avian broilers. The Wuding and Daweishan mini chickens showed higher levels of plasma GH, pituitary GH mRNA but lower levels of hepatic growth hormone receptor (GHR) mRNA than in Avian broilers. Daweishan mini chickens showed significantly lower levels of plasma IGF-1, thigh muscle and hepatic IGF-1 mRNA than did Avian broilers and Wuding chickens. These results suggest that the GH part of the somatotropic axis is the main regulator of growth rate, while IGF-1 may regulate both growth rate and body weight. Selection for growth performance and body size have altered the expression profiles of somatotropic axis genes in a breed-, age-, and tissue-specific manner, and manner, and alteration of regulatory mechanisms of these genes might play an important role in the developmental characteristics of chickens.
Original languageEnglish
Article numbere0195378
JournalPLoS ONE
Volume13
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018

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    Jia, J., Ahmed, I., Liu, L., Liu, Y., Xu, Z., Duan, X., Li, Q., Dou, T., Gu, D., Rong, H., Wang, K., Li, Z., Talpur, M. Z., Huang, Y., Wang, S., Yan, S., Tong, H., Zhao, S., Zhao, G., ... Ge, C. (2018). Selection for growth rate and body size have altered the expression profiles of somatotropic axis genes in chickens. PLoS ONE, 13(4), [e0195378]. https://doi.org/10.1371/journal.pone.0195378