Selection and characterisation of a xylitol-derepressed Aspergillus niger mutant that is apparently impaired in xylitol transport

P.J.I. van de Vondervoort, M.J.L. de Groot, G.J.G. Ruijter, J. Visser

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Aspergillus niger is known for its biotechnological applications, such as the use of xylanase enzyme for the degradation of hemicellulose. Depending on culture conditions, several polyols may also be accumulated, such as xylitol during D-xylose oxidation. Also during industrial fermentation of xylose for the production of fuel ethanol by recombinant yeast, xylitol is a by-product. We studied xylitol metabolism by isolating mutants that have impaired xylitol-mediated repression. Genetic and biochemical characterisation revealed that one of these mutants was affected not only in xylitol-mediated carbon repression, but also had impaired xylitol transport
Original languageEnglish
Pages (from-to)881-886
JournalApplied Microbiology and Biotechnology
Volume73
Issue number4
DOIs
Publication statusPublished - 2006

Keywords

  • metabolic-control analysis
  • saccharomyces-cerevisiae
  • l-arabinose
  • xylose catabolism
  • fermentation
  • xylan
  • construction
  • degradation
  • nidulans
  • genes

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