Searching for interacting QTL in related populations of an outbreeding species

J. Jansen, M.P. Boer, M.C.A.M. Bink, W.E. van de Weg

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)


Many important crop species are outbreeding. In outbreeding species the search for genes affecting traits is complicated by the fact that in a single cross up to four alleles may be present at each locus. This paper is concerned with the search for interacting quantitative trait loci (QTL) in populations which have been obtained by crossing a number of parents. It will be assumed that the parents are unrelated, but the methods can be extended easily to allow a pedigree structure. The approach has two goals: (1) finding QTL that are interacting with other loci and also loci which behave additively; (2) finding parents which segregate at two or more interacting QTL. Large populations obtained by crossing these parents can be used to study interactions in detail. QTL analysis is carried out by means of regression on predictions of QTL genotypes.
Original languageEnglish
Pages (from-to)131-144
Issue number1
Publication statusPublished - 2009


  • quantitative trait loci
  • dimensional genome searches
  • variance-components
  • epistasis
  • models
  • pedigrees

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