Screening of the needles of different yew species and cultivars for paclitaxel and related taxoids

E.L.M. van Rozendaal, G.P. Lelyveld, T.A. van Beek

Research output: Contribution to journalArticleAcademicpeer-review

84 Citations (Scopus)

Abstract

The needles of several yew species and cultivars were analysed by high-pressure liquid chromatography for paclitaxel, 10-deacetylpaclitaxel, cephalomannine, baccatin III, 10-deacetylbaccatin III and brevifoliol. About 750 samples were collected from five different locations in the Netherlands and the UK. The results of this screening show a large variation in taxane content between the different species and cultivars. The content of paclitaxel and 10-deacetylbaccatin III varied from 0 to 500 micrograms/g and 0 to 4800 micrograms/g dried needles, respectively. Brevifoliol was found in a very high concentration in Taxus brevifolia. 10-Deacetylpaclitaxel, cephalomannine and baccatin III were found in concentrations ranging from 0 to 500 micrograms/g dried needles.
Original languageEnglish
Pages (from-to)383-389
JournalPhytochemistry
Volume53
DOIs
Publication statusPublished - 2000

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