TY - JOUR
T1 - Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry
AU - Peters, R.J.B.
AU - Stolker, A.A.M.
AU - Mol, J.G.J.
AU - Lommen, A.
AU - Lyris, E.
AU - Angelis, Y.S.
AU - Vonaparti, A.
AU - Stamou, M.
AU - Georgakopoulos, C.G.
AU - Nielen, M.W.F.
PY - 2010
Y1 - 2010
N2 - A common trend in food contaminants and sports doping control is towards a limited number of targeted, full-scan, accurate-mass spectrometry (MS) methods based on time-of-flight (TOF) or Fourier-transform orbital trap (Orbitrap) mass analyzers. Retrospective analysis of the full-scan datasets of signals from emerging contaminants, novel metabolites and illegal designer substances is a major step forward.
We present data from recent applications of gas chromatography with TOF-MS, ultra-high-performance liquid chromatography (LC) with TOF-MS and LC-Orbitrap MS in the screening of European Commission-regulated veterinary drugs and other contaminants in foods, and World Anti-Doping Agency-prohibited substances. We discuss the potential impact of these new approaches on future developments.
AB - A common trend in food contaminants and sports doping control is towards a limited number of targeted, full-scan, accurate-mass spectrometry (MS) methods based on time-of-flight (TOF) or Fourier-transform orbital trap (Orbitrap) mass analyzers. Retrospective analysis of the full-scan datasets of signals from emerging contaminants, novel metabolites and illegal designer substances is a major step forward.
We present data from recent applications of gas chromatography with TOF-MS, ultra-high-performance liquid chromatography (LC) with TOF-MS and LC-Orbitrap MS in the screening of European Commission-regulated veterinary drugs and other contaminants in foods, and World Anti-Doping Agency-prohibited substances. We discuss the potential impact of these new approaches on future developments.
KW - growth-promoting agents
KW - horse urine analysis
KW - uplc-tof-ms
KW - liquid-chromatography
KW - residue analysis
KW - gas-chromatography
KW - metabolite identification
KW - threshold substances
KW - organic pollutants
KW - unknown pesticides
U2 - 10.1016/j.trac.2010.07.012
DO - 10.1016/j.trac.2010.07.012
M3 - Article
SN - 0165-9936
VL - 29
SP - 1250
EP - 1268
JO - TrAC : Trends in Analytical Chemistry
JF - TrAC : Trends in Analytical Chemistry
IS - 11
ER -