Screening for gestagens in kidney fat using accelerated solvent extraction and liquid chromatography electrospray tandem mass spectrometry

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Abstract

A screening method has been developed for the determination of various anabolic steroids in kidney fat. Fat samples are extracted and steroids are trapped "on-line" during accelerated solvent extraction (ASE). Following this initial extraction samples are further purified with C18 solid-phase extraction (SPE). Compounds were finally analyzed by liquid chromatography (LC) coupled with tandem mass spectrometry (MS). The method was validated using blank kidney fat and fat samples fortified at 2 ng g-1. The detection capability (CC) was
Original languageEnglish
Pages (from-to)51-59
JournalAnalytica Chimica Acta
Volume483
Issue number1-2
DOIs
Publication statusPublished - 2003

Keywords

  • supercritical-fluid extraction
  • tissues
  • steroids

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