Abstract
The aim of this study was to use fecal metabolite profiling to evaluate the effects of contrasting sanitary conditions and the associated subclinical health status of pigs. We analyzed fecal metabolite profiles by nuclear magnetic resonance (1 H NMR) from pigs aged 14 and 22 weeks. Pigs kept under low and high sanitary conditions differed in fecal metabolites related to the degradation of dietary starch, metabolism of the gut microbiome, and degradation of components of animal (host) origin. The metabolites that differed significantly (FDR < 0.1) were from metabolic processes involved in either maintaining nutrient digestive capacity, including purine metabolism, energy metabolism, bile acid breakdown and recycling, or immune system metabolism. The results show that the fecal metabolite profiles reflect the sanitary conditions under which the pigs are kept. The fecal metabolite profiles closely resembled the profiles of metabolites found in the colon of pigs. Fecal valerate and kynurenic acid could potentially be used as “non-invasive” biomarkers of immune or inflammatory status that could form the basis for monitoring subclinical health status in pigs.
Original language | English |
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Article number | 538 |
Journal | Metabolites |
Volume | 12 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2022 |
Keywords
- feces
- health
- immune
- metabolomics
- nuclear magnetic resonance
- pig
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raw NMR dataset + metadata
Schokker, D. (Creator), Kar, S. K. (Creator) & Jansman, A. J. M. (Creator), Wageningen University & Research, 15 Dec 2021
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Potential of fecal metabolites as biomarkers for pig health
26/10/22
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Press/Media: Research › Popular