Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium

T. van Straaten; R. Janssen; D.J. Mevius; J.T. van Dissel

doi:10.1128/AAC.48.6.2292-2294.2004

Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium

T. van Straaten, R. Janssen, D.J. Mevius, J.T. van Dissel

Laboratory of Nematology

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Scopus)

Abstract

MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella

Original language	English
Pages (from-to)	2292-2294
Journal	Antimicrobial Agents and Chemotherapy
Volume	48
Issue number	6
DOIs	https://doi.org/10.1128/AAC.48.6.2292-2294.2004
Publication status	Published - 2004

Keywords

escherichia-coli
antibiotic-resistance
virulence
confers
mutants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.48.6.2292-2294.2004

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title = "Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium",

abstract = "MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella",

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author = "{van Straaten}, T. and R. Janssen and D.J. Mevius and {van Dissel}, J.T.",

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language = "English",

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TY - JOUR

T1 - Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium

AU - van Straaten, T.

AU - Janssen, R.

AU - Mevius, D.J.

AU - van Dissel, J.T.

PY - 2004

Y1 - 2004

N2 - MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella

AB - MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella

KW - escherichia-coli

KW - antibiotic-resistance

KW - virulence

KW - confers

KW - mutants

U2 - 10.1128/AAC.48.6.2292-2294.2004

DO - 10.1128/AAC.48.6.2292-2294.2004

M3 - Article

SN - 0066-4804

VL - 48

SP - 2292

EP - 2294

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium

Abstract

Keywords

UN SDGs

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