Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium

T. van Straaten, R. Janssen, D.J. Mevius, J.T. van Dissel

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Abstract

MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella
Original languageEnglish
Pages (from-to)2292-2294
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number6
DOIs
Publication statusPublished - 2004

Keywords

  • escherichia-coli
  • antibiotic-resistance
  • virulence
  • confers
  • mutants

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