Salivary biomarkers associated with perceived satiety and body mass in humans

L.F. Harthoorn, R.G. Schipper, A. Loof, W. van Heerde, J.H.G. Cordewener, A.H.P. America, P.F.G. Vereijken, E. Dransfield

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)


Regulation of food intake and energy homeostasis is controlled by a delicate balancing of numerous central and peripheral factors, including circulating peptide hormones. This study investigated the proteome of saliva using SELDI-TOF-MS in relation to satiety and body mass index (BMI) in humans. Within a longitudinal test session, 18 subjects were exposed to a lunch-induced hunger-satiety shift, while every 15 min collecting their whole saliva and rating their hunger and satiety. Saliva was analysed by SELDI-TOF-MS using IMAC arrays with a chromatographic copper surface (IMAC-Cu). From all subjects and time points measured, peptide and protein profiles showed 190 common peaks. Their interrelationships show that 37% of the variation was accounted for in one dimension. About 30 means had a strong association (0.70
Original languageEnglish
Pages (from-to)1637-1650
JournalProteomics Clinical Applications
Issue number12
Publication statusPublished - 2007


  • 2-dimensional gel-electrophoresis
  • human whole saliva
  • proteomic analysis
  • food-intake
  • ionization-time
  • spectrometry
  • ghrelin
  • identification
  • insulin
  • histatins


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