S-arylation of mercaptobenzimidazoles using Cu(I) catalysts-experimental and theoretical observations

R. Sekar, M. Srinivasan, A.T.M. Marcelis, A. Sambandam

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24 Citations (Scopus)


Substituted 2-mercaptobenzimidazoles (MBI) are an important class of bio-active and industrially important organic compounds. In this Letter, a new synthetic method is presented for the selective S-arylation of MBI with substituted aryl iodides using low cost copper (I) iodide and 1,10-phenanthroline as a catalytic system. The selective formation of S-arylated product was confirmed by several spectroscopic techniques and the vibrational spectrum was found to be in very good agreement with the theoretical spectrum calculated by density functional theory
Original languageEnglish
Pages (from-to)3347-3352
JournalTetrahedron Letters
Issue number26
Publication statusPublished - 2011


  • aryl halides
  • nucleophilic-substitution
  • coupling reactions
  • bond formation
  • thiols
  • efficient
  • derivatives
  • inhibitors
  • iodides
  • density

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