Ruphus-mediated Suzuki cross-coupling of secondary alkyl trifluoroborates

A. van den Hoogenband, J.H.M. Lange, J.W. Terpstra, M. Koch, G.M. Visser, M. de Visser, T.J. Korstanje, J.T.B.H. Jastrzebski

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A Ruphos-mediated Suzuki cross-coupling between (hetero)aryl bromides and secondary alkyltrifluoroborates is described using palladium catalysis. The Ruphos ligand showed superior properties as compared to S-Phos in this type of reaction. This method constitutes a valuable extension to current methods for the straightforward production of secondary-alkylated (hetero)aryl derivatives.
Original languageEnglish
Pages (from-to)4122-4124
JournalTetrahedron Letters
Issue number26
Publication statusPublished - 2008


  • palladium-catalyzed reactions
  • aryl halides
  • cyclopropylboronic acids
  • arylboronic acids
  • miyaura reaction
  • potassium aryl
  • organic-synthesis
  • active catalyst
  • boronic acids
  • efficient

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