Role of vaccination-induced immunity and antigenic distance in the transmission of highly pathogenic avian influenza H5N1.

I. Sitaras, X. Rousou, D. Kalthoff, M. Beer, B.P.H. Peeters, M.C.M. de Jong

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Highly pathogenic avian influenza (HPAI) H5N1 epidemics in poultry cause
huge economic losses as well as sporadic human morbidity and mortality.
Vaccination in poultry has often been reported as being ineffective in preventing
transmission and as a potential driving force in the selection of immune
escape mutants.We conducted transmission experiments to evaluate the transmission
dynamics of HPAI H5N1 strains in chickens vaccinated with high and
low doses of immune escape mutants we have previously selected, and analysed
the data using mathematical models. Remarkably, we demonstrate
that the effect of antigenic distances between the vaccine and challenge strains
used in this study is too small to influence the transmission dynamics of the
strains used. This is because the effect of a sufficient vaccine dose on antibody
levels against the challenge viruses is large enough to compensate for any
decrease in antibody titres due to antigenic differences between vaccine and
challenge strains. Our results showthat at least under experimental conditions,
vaccination will remain effective even after antigenic changes as may be
caused by the initial selection in vaccinated birds.
Original languageEnglish
Article number20150976
Number of pages13
JournalJournal of the Royal Society, Interface
Volume13
Issue number114
DOIs
Publication statusPublished - 2016

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Influenza in Birds
Vaccines
Immunity
Poultry
Vaccination
Birds
Viruses
Antibodies
Chickens
Theoretical Models
Economics
Mathematical models
Morbidity
Mortality
Experiments

Keywords

  • highly pathogenic avian influenza
  • transmission
  • antigenic distance
  • vaccine dose

Cite this

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title = "Role of vaccination-induced immunity and antigenic distance in the transmission of highly pathogenic avian influenza H5N1.",
abstract = "Highly pathogenic avian influenza (HPAI) H5N1 epidemics in poultry causehuge economic losses as well as sporadic human morbidity and mortality.Vaccination in poultry has often been reported as being ineffective in preventingtransmission and as a potential driving force in the selection of immuneescape mutants.We conducted transmission experiments to evaluate the transmissiondynamics of HPAI H5N1 strains in chickens vaccinated with high andlow doses of immune escape mutants we have previously selected, and analysedthe data using mathematical models. Remarkably, we demonstratethat the effect of antigenic distances between the vaccine and challenge strainsused in this study is too small to influence the transmission dynamics of thestrains used. This is because the effect of a sufficient vaccine dose on antibodylevels against the challenge viruses is large enough to compensate for anydecrease in antibody titres due to antigenic differences between vaccine andchallenge strains. Our results showthat at least under experimental conditions,vaccination will remain effective even after antigenic changes as may becaused by the initial selection in vaccinated birds.",
keywords = "highly pathogenic avian influenza , transmission, antigenic distance, vaccine dose",
author = "I. Sitaras and X. Rousou and D. Kalthoff and M. Beer and B.P.H. Peeters and {de Jong}, M.C.M.",
year = "2016",
doi = "10.1098/rsif.2015.0976",
language = "English",
volume = "13",
journal = "Journal of the Royal Society, Interface",
issn = "1742-5689",
publisher = "Royal Society of London",
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Role of vaccination-induced immunity and antigenic distance in the transmission of highly pathogenic avian influenza H5N1. / Sitaras, I.; Rousou, X.; Kalthoff, D.; Beer, M.; Peeters, B.P.H.; de Jong, M.C.M.

In: Journal of the Royal Society, Interface, Vol. 13, No. 114, 20150976, 2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Role of vaccination-induced immunity and antigenic distance in the transmission of highly pathogenic avian influenza H5N1.

AU - Sitaras, I.

AU - Rousou, X.

AU - Kalthoff, D.

AU - Beer, M.

AU - Peeters, B.P.H.

AU - de Jong, M.C.M.

PY - 2016

Y1 - 2016

N2 - Highly pathogenic avian influenza (HPAI) H5N1 epidemics in poultry causehuge economic losses as well as sporadic human morbidity and mortality.Vaccination in poultry has often been reported as being ineffective in preventingtransmission and as a potential driving force in the selection of immuneescape mutants.We conducted transmission experiments to evaluate the transmissiondynamics of HPAI H5N1 strains in chickens vaccinated with high andlow doses of immune escape mutants we have previously selected, and analysedthe data using mathematical models. Remarkably, we demonstratethat the effect of antigenic distances between the vaccine and challenge strainsused in this study is too small to influence the transmission dynamics of thestrains used. This is because the effect of a sufficient vaccine dose on antibodylevels against the challenge viruses is large enough to compensate for anydecrease in antibody titres due to antigenic differences between vaccine andchallenge strains. Our results showthat at least under experimental conditions,vaccination will remain effective even after antigenic changes as may becaused by the initial selection in vaccinated birds.

AB - Highly pathogenic avian influenza (HPAI) H5N1 epidemics in poultry causehuge economic losses as well as sporadic human morbidity and mortality.Vaccination in poultry has often been reported as being ineffective in preventingtransmission and as a potential driving force in the selection of immuneescape mutants.We conducted transmission experiments to evaluate the transmissiondynamics of HPAI H5N1 strains in chickens vaccinated with high andlow doses of immune escape mutants we have previously selected, and analysedthe data using mathematical models. Remarkably, we demonstratethat the effect of antigenic distances between the vaccine and challenge strainsused in this study is too small to influence the transmission dynamics of thestrains used. This is because the effect of a sufficient vaccine dose on antibodylevels against the challenge viruses is large enough to compensate for anydecrease in antibody titres due to antigenic differences between vaccine andchallenge strains. Our results showthat at least under experimental conditions,vaccination will remain effective even after antigenic changes as may becaused by the initial selection in vaccinated birds.

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KW - transmission

KW - antigenic distance

KW - vaccine dose

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SN - 1742-5689

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