Role of the Environment in the Transmission of Antimicrobial Resistance to Humans: A Review

P.M.C. Huijbers, H. Blaak, M.C.M. de Jong, E.A.M. Graat, C.M.J.E. Vandenbroucke-Grauls, A.M. de Roda Husman

Research output: Contribution to journalArticleAcademicpeer-review

102 Citations (Scopus)

Abstract

To establish a possible role for the natural environment in the transmission of clinically relevant AMR bacteria to humans, a literature review was conducted to systematically collect and categorize evidence for human exposure to extended-spectrum ß-lactamase-producing Enterobacteriaceae, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus spp. in the environment. In total, 239 datasets adhered to inclusion criteria. AMR bacteria were detected at exposure-relevant sites (35/38), including recreational areas, drinking water, ambient air, and shellfish, and in fresh produce (8/16). More datasets were available for environmental compartments (139/157), including wildlife, water, soil, and air/dust. Quantitative data from exposure-relevant sites (6/35) and environmental compartments (11/139) were scarce. AMR bacteria were detected in the contamination sources (66/66) wastewater and manure, and molecular data supporting their transmission from wastewater to the environment (1/66) were found. The abundance of AMR bacteria at exposure-relevant sites suggests risk for human exposure. Of publications pertaining to both environmental and human isolates, however, only one compared isolates from samples that had a clear spatial and temporal relationship, and no direct evidence was found for transmission to humans through the environment. To what extent the environment, compared to the clinical and veterinary domains, contributes to human exposure needs to be quantified. AMR bacteria in the environment, including sites relevant for human exposure, originate from contamination sources. Intervention strategies targeted at these sources could therefore limit emission of AMR bacteria to the environment
Original languageEnglish
Pages (from-to)11993-12004
JournalEnvironmental Science and Technology
Volume49
Issue number20
DOIs
Publication statusPublished - 2015

Fingerprint

Bacteria
bacterium
Wastewater
Contamination
Shellfish
Methicillin
Manures
wastewater
Vancomycin
Air
Drinking Water
shellfish
Dust
exposure
literature review
ambient air
manure
Soils
soil water
drinking water

Cite this

Huijbers, P.M.C. ; Blaak, H. ; de Jong, M.C.M. ; Graat, E.A.M. ; Vandenbroucke-Grauls, C.M.J.E. ; de Roda Husman, A.M. / Role of the Environment in the Transmission of Antimicrobial Resistance to Humans: A Review. In: Environmental Science and Technology. 2015 ; Vol. 49, No. 20. pp. 11993-12004.
@article{dbb79880fb6a4c4eab99a3b43051fa58,
title = "Role of the Environment in the Transmission of Antimicrobial Resistance to Humans: A Review",
abstract = "To establish a possible role for the natural environment in the transmission of clinically relevant AMR bacteria to humans, a literature review was conducted to systematically collect and categorize evidence for human exposure to extended-spectrum {\ss}-lactamase-producing Enterobacteriaceae, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus spp. in the environment. In total, 239 datasets adhered to inclusion criteria. AMR bacteria were detected at exposure-relevant sites (35/38), including recreational areas, drinking water, ambient air, and shellfish, and in fresh produce (8/16). More datasets were available for environmental compartments (139/157), including wildlife, water, soil, and air/dust. Quantitative data from exposure-relevant sites (6/35) and environmental compartments (11/139) were scarce. AMR bacteria were detected in the contamination sources (66/66) wastewater and manure, and molecular data supporting their transmission from wastewater to the environment (1/66) were found. The abundance of AMR bacteria at exposure-relevant sites suggests risk for human exposure. Of publications pertaining to both environmental and human isolates, however, only one compared isolates from samples that had a clear spatial and temporal relationship, and no direct evidence was found for transmission to humans through the environment. To what extent the environment, compared to the clinical and veterinary domains, contributes to human exposure needs to be quantified. AMR bacteria in the environment, including sites relevant for human exposure, originate from contamination sources. Intervention strategies targeted at these sources could therefore limit emission of AMR bacteria to the environment",
author = "P.M.C. Huijbers and H. Blaak and {de Jong}, M.C.M. and E.A.M. Graat and C.M.J.E. Vandenbroucke-Grauls and {de Roda Husman}, A.M.",
year = "2015",
doi = "10.1021/acs.est.5b02566",
language = "English",
volume = "49",
pages = "11993--12004",
journal = "Environmental Science and Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "20",

}

Role of the Environment in the Transmission of Antimicrobial Resistance to Humans: A Review. / Huijbers, P.M.C.; Blaak, H.; de Jong, M.C.M.; Graat, E.A.M.; Vandenbroucke-Grauls, C.M.J.E.; de Roda Husman, A.M.

In: Environmental Science and Technology, Vol. 49, No. 20, 2015, p. 11993-12004.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Role of the Environment in the Transmission of Antimicrobial Resistance to Humans: A Review

AU - Huijbers, P.M.C.

AU - Blaak, H.

AU - de Jong, M.C.M.

AU - Graat, E.A.M.

AU - Vandenbroucke-Grauls, C.M.J.E.

AU - de Roda Husman, A.M.

PY - 2015

Y1 - 2015

N2 - To establish a possible role for the natural environment in the transmission of clinically relevant AMR bacteria to humans, a literature review was conducted to systematically collect and categorize evidence for human exposure to extended-spectrum ß-lactamase-producing Enterobacteriaceae, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus spp. in the environment. In total, 239 datasets adhered to inclusion criteria. AMR bacteria were detected at exposure-relevant sites (35/38), including recreational areas, drinking water, ambient air, and shellfish, and in fresh produce (8/16). More datasets were available for environmental compartments (139/157), including wildlife, water, soil, and air/dust. Quantitative data from exposure-relevant sites (6/35) and environmental compartments (11/139) were scarce. AMR bacteria were detected in the contamination sources (66/66) wastewater and manure, and molecular data supporting their transmission from wastewater to the environment (1/66) were found. The abundance of AMR bacteria at exposure-relevant sites suggests risk for human exposure. Of publications pertaining to both environmental and human isolates, however, only one compared isolates from samples that had a clear spatial and temporal relationship, and no direct evidence was found for transmission to humans through the environment. To what extent the environment, compared to the clinical and veterinary domains, contributes to human exposure needs to be quantified. AMR bacteria in the environment, including sites relevant for human exposure, originate from contamination sources. Intervention strategies targeted at these sources could therefore limit emission of AMR bacteria to the environment

AB - To establish a possible role for the natural environment in the transmission of clinically relevant AMR bacteria to humans, a literature review was conducted to systematically collect and categorize evidence for human exposure to extended-spectrum ß-lactamase-producing Enterobacteriaceae, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus spp. in the environment. In total, 239 datasets adhered to inclusion criteria. AMR bacteria were detected at exposure-relevant sites (35/38), including recreational areas, drinking water, ambient air, and shellfish, and in fresh produce (8/16). More datasets were available for environmental compartments (139/157), including wildlife, water, soil, and air/dust. Quantitative data from exposure-relevant sites (6/35) and environmental compartments (11/139) were scarce. AMR bacteria were detected in the contamination sources (66/66) wastewater and manure, and molecular data supporting their transmission from wastewater to the environment (1/66) were found. The abundance of AMR bacteria at exposure-relevant sites suggests risk for human exposure. Of publications pertaining to both environmental and human isolates, however, only one compared isolates from samples that had a clear spatial and temporal relationship, and no direct evidence was found for transmission to humans through the environment. To what extent the environment, compared to the clinical and veterinary domains, contributes to human exposure needs to be quantified. AMR bacteria in the environment, including sites relevant for human exposure, originate from contamination sources. Intervention strategies targeted at these sources could therefore limit emission of AMR bacteria to the environment

U2 - 10.1021/acs.est.5b02566

DO - 10.1021/acs.est.5b02566

M3 - Article

VL - 49

SP - 11993

EP - 12004

JO - Environmental Science and Technology

JF - Environmental Science and Technology

SN - 0013-936X

IS - 20

ER -