Role of curcumin in the conversion of asparagine into acrylamide during heating

Aytül Hamzalioǧlu, Burçe A. Mogol, Roberta Barone Lumaga, Vincenzo Fogliano, Vural Gökmen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)


This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompetitive reaction conditions. The results indicated that curcumin could potentially contribute to acrylamide formation under long-term heating conditions as long as asparagine was present in the medium. The amount of acrylamide formed in the ternary system was slightly higher than in the binary system during heating (p < 0.05), because of the higher concentrations of carbonyl compounds initially available. The kinetic trends were similar in both model systems evidencing that fructose reacted with asparagine more rapidly than curcumin. The data reveal that acrylamide formation in the temperature range of 150-200 C obeys Arrhenius law with activation energy of 79.1 kJ/mole. Data of this work showed the possibility that antioxidants having a carbonyl compound can react directly with ASN leading to acrylamide. The addition of antioxidants to foods may increase the formation of acrylamide upon long-term heating if free sugar concentration is low and ASN concentration is relatively high.

Original languageEnglish
Pages (from-to)1419-1426
Number of pages8
JournalAmino Acids
Issue number6
Publication statusPublished - 1 Jun 2013
Externally publishedYes


  • Acrylamide formation
  • Asparagine
  • Curcumin
  • Maillard reaction

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