Rodent Overview

Nina Zupanic, J. Keijer, K.J. Teerds

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Due to their physiological and genetic resemblance to humans, rodents are one of the most commonly used model organisms and have contributed significantly to our knowledge on male reproduction. In this article, a selection of rodent models is discussed that have added enormously to our understanding of, particularly, male fertility. These rodent models are: the spermatogonial stem cell transplantation model, the ethane-1,2-dimethyl sulphonate (EDS) model for Leydig cell development, and models that contributed to our understanding of the dangers of fetal exposure to environmental chemicals leading to TDS, the testicular dysgenesis syndrome.
Original languageEnglish
Title of host publicationEncyclopedia of reproduction
EditorsM.K. Skinner
ISBN (Electronic)9780128151457
ISBN (Print)9780128118993
Publication statusPublished - 30 Jul 2018


  • Di-n-butyl phthalate (DBP)
  • Ethane dimethyl sulphonate (EDS)
  • Leydig cells
  • Regeneration
  • Rodent models
  • Spermatogenesis
  • Spermatogonial stem cells (SSC’s)
  • Testicular dysgenesis syndrome (TDS)
  • Testis
  • Transplantation


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