Risk assessment of combined exposure to alkenylbenzenes through consumption of plant food supplements containing parsley and dill

Abdalmajeed M. Alajlouni, Amer J. Al-Malahmeh, Sebastiaan Wesseling, Marina Kalli, Jacques Vervoort, Ivonne M.C.M. Rietjens

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Abstract

A risk assessment was performed of parsley- and dill-based plant food supplements (PFS) containing apiol and related alkenylbenzenes. First, the levels of the alkenylbenzenes in the PFS and the resulting estimated daily intake (EDI) resulting from use of the PFS were quantified. Since most PFS appeared to contain more than one alkenylbenzene, a combined risk assessment was performed based on equal potency or using a so-called toxic equivalency (TEQ) approach based on toxic equivalency factors (TEFs) for the different alkenylbenzenes. The EDIs resulting from daily PFS consumption amount to 0.74–125 µg kg–1 bw for the individual alkenylbenzenes, 0.74–160 µg kg–1 bw for the sum of the alkenylbenzenes, and 0.47–64 µg kg–1 bw for the sum of alkenylbenzenes when expressed in safrole equivalents. The margins of exposure (MOEs) obtained were generally below 10,000, indicating a priority for risk management if the PFS were to be consumed on a daily basis. Considering short-term use of the PFS, MOEs would increase above 10,000, indicating low priority for risk management. It is concluded that alkenylbenzene intake through consumption of parsley- and dill-based PFS is only of concern when these PFS are used for long periods of time.
Original languageEnglish
Pages (from-to)2201-2211
JournalFood Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Volume34
Issue number12
Early online date28 Jun 2017
DOIs
Publication statusPublished - Dec 2017

Fingerprint

Anethum graveolens
Petroselinum
dill
parsley
Dietary Supplements
Risk assessment
risk assessment
dietary supplements
Poisons
risk management
Risk Management
Risk management
Safrole
safrole
average daily intake
Electronic data interchange

Keywords

  • alkenylbenzenes
  • estimated daily intake
  • margin of exposure
  • Parsley- and dill-based plant food supplements (PFS)
  • risk assessment
  • toxic equivalency approach

Cite this

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title = "Risk assessment of combined exposure to alkenylbenzenes through consumption of plant food supplements containing parsley and dill",
abstract = "A risk assessment was performed of parsley- and dill-based plant food supplements (PFS) containing apiol and related alkenylbenzenes. First, the levels of the alkenylbenzenes in the PFS and the resulting estimated daily intake (EDI) resulting from use of the PFS were quantified. Since most PFS appeared to contain more than one alkenylbenzene, a combined risk assessment was performed based on equal potency or using a so-called toxic equivalency (TEQ) approach based on toxic equivalency factors (TEFs) for the different alkenylbenzenes. The EDIs resulting from daily PFS consumption amount to 0.74–125 µg kg–1 bw for the individual alkenylbenzenes, 0.74–160 µg kg–1 bw for the sum of the alkenylbenzenes, and 0.47–64 µg kg–1 bw for the sum of alkenylbenzenes when expressed in safrole equivalents. The margins of exposure (MOEs) obtained were generally below 10,000, indicating a priority for risk management if the PFS were to be consumed on a daily basis. Considering short-term use of the PFS, MOEs would increase above 10,000, indicating low priority for risk management. It is concluded that alkenylbenzene intake through consumption of parsley- and dill-based PFS is only of concern when these PFS are used for long periods of time.",
keywords = "alkenylbenzenes, estimated daily intake, margin of exposure, Parsley- and dill-based plant food supplements (PFS), risk assessment, toxic equivalency approach",
author = "Alajlouni, {Abdalmajeed M.} and Al-Malahmeh, {Amer J.} and Sebastiaan Wesseling and Marina Kalli and Jacques Vervoort and Rietjens, {Ivonne M.C.M.}",
year = "2017",
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T1 - Risk assessment of combined exposure to alkenylbenzenes through consumption of plant food supplements containing parsley and dill

AU - Alajlouni, Abdalmajeed M.

AU - Al-Malahmeh, Amer J.

AU - Wesseling, Sebastiaan

AU - Kalli, Marina

AU - Vervoort, Jacques

AU - Rietjens, Ivonne M.C.M.

PY - 2017/12

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N2 - A risk assessment was performed of parsley- and dill-based plant food supplements (PFS) containing apiol and related alkenylbenzenes. First, the levels of the alkenylbenzenes in the PFS and the resulting estimated daily intake (EDI) resulting from use of the PFS were quantified. Since most PFS appeared to contain more than one alkenylbenzene, a combined risk assessment was performed based on equal potency or using a so-called toxic equivalency (TEQ) approach based on toxic equivalency factors (TEFs) for the different alkenylbenzenes. The EDIs resulting from daily PFS consumption amount to 0.74–125 µg kg–1 bw for the individual alkenylbenzenes, 0.74–160 µg kg–1 bw for the sum of the alkenylbenzenes, and 0.47–64 µg kg–1 bw for the sum of alkenylbenzenes when expressed in safrole equivalents. The margins of exposure (MOEs) obtained were generally below 10,000, indicating a priority for risk management if the PFS were to be consumed on a daily basis. Considering short-term use of the PFS, MOEs would increase above 10,000, indicating low priority for risk management. It is concluded that alkenylbenzene intake through consumption of parsley- and dill-based PFS is only of concern when these PFS are used for long periods of time.

AB - A risk assessment was performed of parsley- and dill-based plant food supplements (PFS) containing apiol and related alkenylbenzenes. First, the levels of the alkenylbenzenes in the PFS and the resulting estimated daily intake (EDI) resulting from use of the PFS were quantified. Since most PFS appeared to contain more than one alkenylbenzene, a combined risk assessment was performed based on equal potency or using a so-called toxic equivalency (TEQ) approach based on toxic equivalency factors (TEFs) for the different alkenylbenzenes. The EDIs resulting from daily PFS consumption amount to 0.74–125 µg kg–1 bw for the individual alkenylbenzenes, 0.74–160 µg kg–1 bw for the sum of the alkenylbenzenes, and 0.47–64 µg kg–1 bw for the sum of alkenylbenzenes when expressed in safrole equivalents. The margins of exposure (MOEs) obtained were generally below 10,000, indicating a priority for risk management if the PFS were to be consumed on a daily basis. Considering short-term use of the PFS, MOEs would increase above 10,000, indicating low priority for risk management. It is concluded that alkenylbenzene intake through consumption of parsley- and dill-based PFS is only of concern when these PFS are used for long periods of time.

KW - alkenylbenzenes

KW - estimated daily intake

KW - margin of exposure

KW - Parsley- and dill-based plant food supplements (PFS)

KW - risk assessment

KW - toxic equivalency approach

U2 - 10.1080/19440049.2017.1338837

DO - 10.1080/19440049.2017.1338837

M3 - Article

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SP - 2201

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JO - Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment

JF - Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment

SN - 1944-0049

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