“Rim-Differentiated” Pillar[6]arenes

Yang Chao, Tushar Ulhas Thikekar, Wangjian Fang, Rong Chang, Jiong Xu, Nianfeng Ouyang, Jun Xu, Yan Gao, Minjie Guo, Han Zuilhof, Andrew C.H. Sue*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)


A “rim-differentiated” pillar[6]arene (RD-P[6]) was obtained successfully, with the assistance of a dimeric silver trifluoroacetate template, among eight different constitutional isomers in a direct and regioselective manner. The solid-state conformation of this macrocycle could switch from the 1,3,5-alternate to a truly rim-differentiated one upon guest inclusion. This highly symmetric RD-P[6] not only hosts metal-containing molecules inside its cavity, but also can form a pillar[6]arene-C60 adduct through co-crystallization on account of donor-acceptor interactions. The development of synthetic strategies to desymmetrize pillararenes offers new opportunities for engineering complex molecular architectures and organic electronic materials.

Original languageEnglish
JournalAngewandte Chemie - International Edition
Issue number31
Early online date22 Apr 2022
Publication statusPublished - Aug 2022


  • Co-Crystals
  • Host–Guest Chemistry
  • Macrocycles
  • Pillar[n]arenes
  • Tiara[n]arenes


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