Review of analytical approaches for the identification of non-intentionally added substances in paper and board food contact materials

Ruud J.B. Peters, Iris Groeneveld, Patricia Lopez Sanchez, Wouter Gebbink, Arjen Gersen, Monique de Nijs, Stefan P.J. van Leeuwen

Research output: Contribution to journalReview articleAcademicpeer-review

3 Citations (Scopus)

Abstract

Background: Food contact materials (FCM) may contain non-intentionally added substances (NIAS) as a result of reaction by-products, oligomers, degradation processes, chemical reactions between packaging materials and foodstuff, or as impurities from the raw materials used for their production. Scope and approach: In this review, current approaches for the detection and identification of NIAS from paper and board FCM are presented. Reviewed are the definition of NIAS, approaches for NIAS identification and quantification, the comprehensive analysis of NIAS and the role of in silico tools and bioassays. Key Findings and Conclusions: NIAS in paper and board are mostly components from printing inks, adhesives, sizing agents and surface coatings. Recycled paper contains overall more NIAS than fresh paper. Targeted analysis is generally performed for predicted NIAS, whereas an untargeted, or full-scan screening method is applied to detect and identify unpredicted NIAS. Sample preparation and contact conditions fall in two categories; migration and extraction. Migration studies are performed with food simulants while extraction studies are Soxhlet or ultrasound assisted solvent extraction. In untargeted analysis in silico tools are gaining importance in the identification of NIAS. Bioassays are used to determine the bioactivity of extracts or fractions in order to assess the potential toxicity of NIAS present in the mixture. A combination of bioassays and chemical analysis is used to direct the identification of unknown bioactive NIAS in complex mixtures like those from paper and board FCM. However, future research is required into the selection of bioassays since these should not only be sensitive enough for detecting all compounds of concern but should also have a relevance with human health.

LanguageEnglish
Pages44-54
JournalTrends in Food Science and Technology
Volume85
DOIs
Publication statusPublished - 1 Mar 2019

Fingerprint

Biological Assay
bioassays
Food
Computer Simulation
Chemical Phenomena
printing inks
recycled paper
Printing
Ink
packaging materials
Product Packaging
chemical reactions
Complex Mixtures
chemical analysis
adhesives
Adhesives
byproducts
coatings
human health
raw materials

Keywords

  • Bio-assay
  • Chemical analysis
  • Effect directed analysis
  • Food contact materials
  • In silico tools
  • Non-intentionally added substances

Cite this

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title = "Review of analytical approaches for the identification of non-intentionally added substances in paper and board food contact materials",
abstract = "Background: Food contact materials (FCM) may contain non-intentionally added substances (NIAS) as a result of reaction by-products, oligomers, degradation processes, chemical reactions between packaging materials and foodstuff, or as impurities from the raw materials used for their production. Scope and approach: In this review, current approaches for the detection and identification of NIAS from paper and board FCM are presented. Reviewed are the definition of NIAS, approaches for NIAS identification and quantification, the comprehensive analysis of NIAS and the role of in silico tools and bioassays. Key Findings and Conclusions: NIAS in paper and board are mostly components from printing inks, adhesives, sizing agents and surface coatings. Recycled paper contains overall more NIAS than fresh paper. Targeted analysis is generally performed for predicted NIAS, whereas an untargeted, or full-scan screening method is applied to detect and identify unpredicted NIAS. Sample preparation and contact conditions fall in two categories; migration and extraction. Migration studies are performed with food simulants while extraction studies are Soxhlet or ultrasound assisted solvent extraction. In untargeted analysis in silico tools are gaining importance in the identification of NIAS. Bioassays are used to determine the bioactivity of extracts or fractions in order to assess the potential toxicity of NIAS present in the mixture. A combination of bioassays and chemical analysis is used to direct the identification of unknown bioactive NIAS in complex mixtures like those from paper and board FCM. However, future research is required into the selection of bioassays since these should not only be sensitive enough for detecting all compounds of concern but should also have a relevance with human health.",
keywords = "Bio-assay, Chemical analysis, Effect directed analysis, Food contact materials, In silico tools, Non-intentionally added substances",
author = "Peters, {Ruud J.B.} and Iris Groeneveld and Sanchez, {Patricia Lopez} and Wouter Gebbink and Arjen Gersen and {de Nijs}, Monique and {van Leeuwen}, {Stefan P.J.}",
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language = "English",
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journal = "Trends in Food Science and Technology",
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publisher = "Elsevier",

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Review of analytical approaches for the identification of non-intentionally added substances in paper and board food contact materials. / Peters, Ruud J.B.; Groeneveld, Iris; Sanchez, Patricia Lopez; Gebbink, Wouter; Gersen, Arjen; de Nijs, Monique; van Leeuwen, Stefan P.J.

In: Trends in Food Science and Technology, Vol. 85, 01.03.2019, p. 44-54.

Research output: Contribution to journalReview articleAcademicpeer-review

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T1 - Review of analytical approaches for the identification of non-intentionally added substances in paper and board food contact materials

AU - Peters, Ruud J.B.

AU - Groeneveld, Iris

AU - Sanchez, Patricia Lopez

AU - Gebbink, Wouter

AU - Gersen, Arjen

AU - de Nijs, Monique

AU - van Leeuwen, Stefan P.J.

PY - 2019/3/1

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N2 - Background: Food contact materials (FCM) may contain non-intentionally added substances (NIAS) as a result of reaction by-products, oligomers, degradation processes, chemical reactions between packaging materials and foodstuff, or as impurities from the raw materials used for their production. Scope and approach: In this review, current approaches for the detection and identification of NIAS from paper and board FCM are presented. Reviewed are the definition of NIAS, approaches for NIAS identification and quantification, the comprehensive analysis of NIAS and the role of in silico tools and bioassays. Key Findings and Conclusions: NIAS in paper and board are mostly components from printing inks, adhesives, sizing agents and surface coatings. Recycled paper contains overall more NIAS than fresh paper. Targeted analysis is generally performed for predicted NIAS, whereas an untargeted, or full-scan screening method is applied to detect and identify unpredicted NIAS. Sample preparation and contact conditions fall in two categories; migration and extraction. Migration studies are performed with food simulants while extraction studies are Soxhlet or ultrasound assisted solvent extraction. In untargeted analysis in silico tools are gaining importance in the identification of NIAS. Bioassays are used to determine the bioactivity of extracts or fractions in order to assess the potential toxicity of NIAS present in the mixture. A combination of bioassays and chemical analysis is used to direct the identification of unknown bioactive NIAS in complex mixtures like those from paper and board FCM. However, future research is required into the selection of bioassays since these should not only be sensitive enough for detecting all compounds of concern but should also have a relevance with human health.

AB - Background: Food contact materials (FCM) may contain non-intentionally added substances (NIAS) as a result of reaction by-products, oligomers, degradation processes, chemical reactions between packaging materials and foodstuff, or as impurities from the raw materials used for their production. Scope and approach: In this review, current approaches for the detection and identification of NIAS from paper and board FCM are presented. Reviewed are the definition of NIAS, approaches for NIAS identification and quantification, the comprehensive analysis of NIAS and the role of in silico tools and bioassays. Key Findings and Conclusions: NIAS in paper and board are mostly components from printing inks, adhesives, sizing agents and surface coatings. Recycled paper contains overall more NIAS than fresh paper. Targeted analysis is generally performed for predicted NIAS, whereas an untargeted, or full-scan screening method is applied to detect and identify unpredicted NIAS. Sample preparation and contact conditions fall in two categories; migration and extraction. Migration studies are performed with food simulants while extraction studies are Soxhlet or ultrasound assisted solvent extraction. In untargeted analysis in silico tools are gaining importance in the identification of NIAS. Bioassays are used to determine the bioactivity of extracts or fractions in order to assess the potential toxicity of NIAS present in the mixture. A combination of bioassays and chemical analysis is used to direct the identification of unknown bioactive NIAS in complex mixtures like those from paper and board FCM. However, future research is required into the selection of bioassays since these should not only be sensitive enough for detecting all compounds of concern but should also have a relevance with human health.

KW - Bio-assay

KW - Chemical analysis

KW - Effect directed analysis

KW - Food contact materials

KW - In silico tools

KW - Non-intentionally added substances

U2 - 10.1016/j.tifs.2018.12.010

DO - 10.1016/j.tifs.2018.12.010

M3 - Review article

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JO - Trends in Food Science and Technology

T2 - Trends in Food Science and Technology

JF - Trends in Food Science and Technology

SN - 0924-2244

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