TY - JOUR
T1 - Retinol and Riboflavin Supplementation Decreases the Prevalence of Anemia in Chinese Pregnant Women Taking Iron and Folic Acid Supplements 1-3
AU - Aiguo, M.
AU - Schouten, E.G.
AU - Zhang, F.Z.
AU - Kok, F.J.
AU - Yang, F.
AU - Jiang, D.C.
AU - Sun, Y.Y.
AU - Han, X.X.
PY - 2008
Y1 - 2008
N2 - In rural China, many pregnant women in their third trimester suffer from anemia (48%) and iron deficiency (ID; 42%), often with coexisting deficiencies of retinol and riboflavin. We investigated the effect of retinol and riboflavin supplementation in addition to iron plus folic acid on anemia and subjective well-being in pregnant women. The study was a 2-mo, double-blind, randomized trial. Subjects (n = 366) with anemia [hemoglobin (Hb) 105 g/L] were randomly assigned to 4 groups, all receiving 60 mg/d iron and 400 µg/d folic acid. The iron+folic acid (IF) group (n = 93) served as reference, the iron+folic acid+retinol group (IFA) (n = 91) was treated with 2000 µg retinol, the iron+folic acid+riboflavin group (IFB) (n = 91) with 1.0 mg riboflavin, and the iron+folic acid+retinol+riboflavin group (IFAB) (n = 91) with retinol and riboflavin. After the 2-mo intervention, the Hb concentration increased in all 4 groups (P <0.001). The increase in the IFAB group was 5.4 ± 1.1 g/L greater than in the IF group (P <0.001). The reduced prevalence of anemia (Hb <110g/L) and ID anemia were significantly greater in the groups supplemented with retinol and /or riboflavin than in the IF group. Moreover, gastrointestinal symptoms were less prevalent in the IFA group than in the IF group (P <0.05) and improved well-being was more prevalent in the groups receiving additional retinol and/or riboflavin than in the IF group (P <0.05). Thus, a combination of iron, folic acid, retinol, and riboflavin was more effective than iron plus folic acid alone. Multimicronutrient supplementation may be worthwhile for pregnant women in rural China.
AB - In rural China, many pregnant women in their third trimester suffer from anemia (48%) and iron deficiency (ID; 42%), often with coexisting deficiencies of retinol and riboflavin. We investigated the effect of retinol and riboflavin supplementation in addition to iron plus folic acid on anemia and subjective well-being in pregnant women. The study was a 2-mo, double-blind, randomized trial. Subjects (n = 366) with anemia [hemoglobin (Hb) 105 g/L] were randomly assigned to 4 groups, all receiving 60 mg/d iron and 400 µg/d folic acid. The iron+folic acid (IF) group (n = 93) served as reference, the iron+folic acid+retinol group (IFA) (n = 91) was treated with 2000 µg retinol, the iron+folic acid+riboflavin group (IFB) (n = 91) with 1.0 mg riboflavin, and the iron+folic acid+retinol+riboflavin group (IFAB) (n = 91) with retinol and riboflavin. After the 2-mo intervention, the Hb concentration increased in all 4 groups (P <0.001). The increase in the IFAB group was 5.4 ± 1.1 g/L greater than in the IF group (P <0.001). The reduced prevalence of anemia (Hb <110g/L) and ID anemia were significantly greater in the groups supplemented with retinol and /or riboflavin than in the IF group. Moreover, gastrointestinal symptoms were less prevalent in the IFA group than in the IF group (P <0.05) and improved well-being was more prevalent in the groups receiving additional retinol and/or riboflavin than in the IF group (P <0.05). Thus, a combination of iron, folic acid, retinol, and riboflavin was more effective than iron plus folic acid alone. Multimicronutrient supplementation may be worthwhile for pregnant women in rural China.
KW - vitamin-a-deficiency
KW - clinical-trial
KW - folate
KW - adaptation
KW - health
U2 - 10.1093/jn/138.10.1946
DO - 10.1093/jn/138.10.1946
M3 - Article
SN - 0022-3166
VL - 138
SP - 1946
EP - 1950
JO - The Journal of Nutrition
JF - The Journal of Nutrition
IS - 10
ER -