Resistance and susceptibility to late blight in Solanum: gene mapping, cloning and stacking

E.C. Verzaux

Research output: Thesisinternal PhD, WU


The potato late blight disease, caused by the oomycete Phytophthora infestans, is a major threat for potato production worldwide. To breed potato varieties with durable resistance against P. infestans, it is necessary to combine two or more resistance (R) genes. Single R genes are easily overcome by the rapidly evolving pathogen, whereas the presence of several R genes could probably prevent gain of virulence from a single mutation in the pathogen. The large gene pool available within wild potato species offers sufficient possibilities to identify new and diverse R genes conferring resistance to P. infestans (Rpi). Map-based cloning is the most suitable strategy to isolate such new Rpi genes. The objective of this research was mapping, if possible, followed by cloning of Rpi genes from wild Solanum species. Resistance to P. infestans occurring in four different wild Solanum species were mapped in a major R gene cluster on chromosome 11. Natural stacking of three R genes located on different chromosomes was identified in a natural hybrid. In addition, we initiated studies on another type of defense system that is not based on the typical R genes, namely the response of Solanum to INF1 elicitin.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
  • Visser, Richard, Promotor
  • Jacobsen, Evert, Promotor
Award date17 Jun 2010
Place of Publication[S.l.
Print ISBNs9789085856313
Publication statusPublished - 2010


  • phytophthora infestans
  • solanum
  • wild relatives
  • disease resistance
  • gene mapping
  • dna cloning
  • genetic mapping
  • plant breeding
  • resistance breeding


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