Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria

Peter A. Bron*, Barbara Marcelli, Joyce Mulder, Simon van der Els, Luiza P. Morawska, Oscar P. Kuipers, Jan Kok, Michiel Kleerebezem

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

The ever-expanding genomic insight in natural diversity of lactic acid bacteria (LAB) has revived the industrial interest in traditional and natural genetic mobilization methodologies. Here, we review recent advances in horizontal gene transfer processes in LAB, including natural competence, conjugation, and phage transduction. In addition, we envision the possibilities for industrial strain improvement arising from the recent discoveries of molecular exchanges between bacteria through nanotubes and extracellular vesicles, as well as the constantly expanding genome editing possibilities using the CRISPR-Cas technology.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume56
DOIs
Publication statusPublished - 1 Apr 2019

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