Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study

E.M. Brouwer-Brolsma, A.M.M. Vaes, N.L. van der Zwaluw, J.P. van Wijngaarden, K.M.A. Swart, A.C. Ham, S.C. van Dijk, A.W. Enneman, E. Sohl, N.M. van Schoor, N. van der Velde, A.G. Uitterlinden, P. Lips, E.J.M. Feskens, R.A.M. Dhonukshe-Rutten, C.P.G.M. de Groot

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Abstract

Background/objectives The prevalence of vitamin D deficiency among seniors is high. Whereas sun exposure, vitamin D intake, genes, demographics, and lifestyle have been identified as being important determinants of vitamin D status, the impact of these factors is expected to differ across populations. To improve current prevention and treatment strategies, this study aimed to explore the main determinants of vitamin D status and its relative importance in a population of community-dwelling Dutch older adults. Methods/subjects Serum 25-hydroxyvitamin D (25(OH)D) was measured in 2857 adults aged =65 years. Sun exposure was assessed with a structured questionnaire (n = 1012), vitamin D intake using a Food Frequency Questionnaire (n = 596), and data on genetic variation that may affect 25(OH)D status was obtained for 4 genes, DHCR7 (rs12785878), CYP2R1 (rs10741657), GC (rs2282679), and CYP24A1 (rs6013897) (n = 2530). Results Serum 25(OH)D concentrations
Original languageEnglish
Pages (from-to)168-176
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume164
DOIs
Publication statusPublished - 2016

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