Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study

E.M. Brouwer-Brolsma; A.M.M. Vaes; N.L. van der Zwaluw; J.P. van Wijngaarden; K.M.A. Swart; A.C. Ham; S.C. van Dijk; A.W. Enneman; E. Sohl; N.M. van Schoor; N. van der Velde; A.G. Uitterlinden; P. Lips; E.J.M. Feskens; R.A.M. Dhonukshe-Rutten; C.P.G.M. de Groot

doi:10.1016/j.jsbmb.2015.08.008

Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study

E.M. Brouwer-Brolsma^*, A.M.M. Vaes, N.L. van der Zwaluw, J.P. van Wijngaarden, K.M.A. Swart, A.C. Ham, S.C. van Dijk, A.W. Enneman, E. Sohl, N.M. van Schoor, N. van der Velde, A.G. Uitterlinden, P. Lips, E.J.M. Feskens, R.A.M. Dhonukshe-Rutten, C.P.G.M. de Groot

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background/objectives The prevalence of vitamin D deficiency among seniors is high. Whereas sun exposure, vitamin D intake, genes, demographics, and lifestyle have been identified as being important determinants of vitamin D status, the impact of these factors is expected to differ across populations. To improve current prevention and treatment strategies, this study aimed to explore the main determinants of vitamin D status and its relative importance in a population of community-dwelling Dutch older adults. Methods/subjects Serum 25-hydroxyvitamin D (25(OH)D) was measured in 2857 adults aged =65 years. Sun exposure was assessed with a structured questionnaire (n = 1012), vitamin D intake using a Food Frequency Questionnaire (n = 596), and data on genetic variation that may affect 25(OH)D status was obtained for 4 genes, DHCR7 (rs12785878), CYP2R1 (rs10741657), GC (rs2282679), and CYP24A1 (rs6013897) (n = 2530). Results Serum 25(OH)D concentrations

Original language	English
Pages (from-to)	168-176
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	164
DOIs	https://doi.org/10.1016/j.jsbmb.2015.08.008
Publication status	Published - 2016

Keywords

Serum 25-hydroxyvitamin D
Sunlight
Vitamin D intake
Vitamin D related genetic variation
Vitamin D supplement

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jsbmb.2015.08.008

Vitamine B12 en botontkalking bij ouderen (KB-15-004-003, KB-05-001-021)
de Groot, L. (Project Leader)
1/01/08 → 31/12/11
Project: LVVN project

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Brouwer-Brolsma, E. M., Vaes, A. M. M., van der Zwaluw, N. L., van Wijngaarden, J. P., Swart, K. M. A., Ham, A. C., van Dijk, S. C., Enneman, A. W., Sohl, E., van Schoor, N. M., van der Velde, N., Uitterlinden, A. G., Lips, P., Feskens, E. J. M., Dhonukshe-Rutten, R. A. M., & de Groot, C. P. G. M. (2016). Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study. Journal of Steroid Biochemistry and Molecular Biology, 164, 168-176. https://doi.org/10.1016/j.jsbmb.2015.08.008

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title = "Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study",

abstract = "Background/objectives The prevalence of vitamin D deficiency among seniors is high. Whereas sun exposure, vitamin D intake, genes, demographics, and lifestyle have been identified as being important determinants of vitamin D status, the impact of these factors is expected to differ across populations. To improve current prevention and treatment strategies, this study aimed to explore the main determinants of vitamin D status and its relative importance in a population of community-dwelling Dutch older adults. Methods/subjects Serum 25-hydroxyvitamin D (25(OH)D) was measured in 2857 adults aged =65 years. Sun exposure was assessed with a structured questionnaire (n = 1012), vitamin D intake using a Food Frequency Questionnaire (n = 596), and data on genetic variation that may affect 25(OH)D status was obtained for 4 genes, DHCR7 (rs12785878), CYP2R1 (rs10741657), GC (rs2282679), and CYP24A1 (rs6013897) (n = 2530). Results Serum 25(OH)D concentrations",

keywords = "Serum 25-hydroxyvitamin D, Sunlight, Vitamin D intake, Vitamin D related genetic variation, Vitamin D supplement",

author = "E.M. Brouwer-Brolsma and A.M.M. Vaes and {van der Zwaluw}, N.L. and {van Wijngaarden}, J.P. and K.M.A. Swart and A.C. Ham and {van Dijk}, S.C. and A.W. Enneman and E. Sohl and {van Schoor}, N.M. and {van der Velde}, N. and A.G. Uitterlinden and P. Lips and E.J.M. Feskens and R.A.M. Dhonukshe-Rutten and {de Groot}, C.P.G.M.",

year = "2016",

doi = "10.1016/j.jsbmb.2015.08.008",

language = "English",

volume = "164",

pages = "168--176",

journal = "Journal of Steroid Biochemistry and Molecular Biology",

issn = "0960-0760",

publisher = "Elsevier",

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Brouwer-Brolsma, EM, Vaes, AMM, van der Zwaluw, NL, van Wijngaarden, JP, Swart, KMA, Ham, AC, van Dijk, SC, Enneman, AW, Sohl, E, van Schoor, NM, van der Velde, N, Uitterlinden, AG, Lips, P, Feskens, EJM , Dhonukshe-Rutten, RAM & de Groot, CPGM 2016, 'Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study', Journal of Steroid Biochemistry and Molecular Biology, vol. 164, pp. 168-176. https://doi.org/10.1016/j.jsbmb.2015.08.008

TY - JOUR

T1 - Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study

AU - Brouwer-Brolsma, E.M.

AU - Vaes, A.M.M.

AU - van der Zwaluw, N.L.

AU - van Wijngaarden, J.P.

AU - Swart, K.M.A.

AU - Ham, A.C.

AU - van Dijk, S.C.

AU - Enneman, A.W.

AU - Sohl, E.

AU - van Schoor, N.M.

AU - van der Velde, N.

AU - Uitterlinden, A.G.

AU - Lips, P.

AU - Feskens, E.J.M.

AU - Dhonukshe-Rutten, R.A.M.

AU - de Groot, C.P.G.M.

PY - 2016

Y1 - 2016

N2 - Background/objectives The prevalence of vitamin D deficiency among seniors is high. Whereas sun exposure, vitamin D intake, genes, demographics, and lifestyle have been identified as being important determinants of vitamin D status, the impact of these factors is expected to differ across populations. To improve current prevention and treatment strategies, this study aimed to explore the main determinants of vitamin D status and its relative importance in a population of community-dwelling Dutch older adults. Methods/subjects Serum 25-hydroxyvitamin D (25(OH)D) was measured in 2857 adults aged =65 years. Sun exposure was assessed with a structured questionnaire (n = 1012), vitamin D intake using a Food Frequency Questionnaire (n = 596), and data on genetic variation that may affect 25(OH)D status was obtained for 4 genes, DHCR7 (rs12785878), CYP2R1 (rs10741657), GC (rs2282679), and CYP24A1 (rs6013897) (n = 2530). Results Serum 25(OH)D concentrations

AB - Background/objectives The prevalence of vitamin D deficiency among seniors is high. Whereas sun exposure, vitamin D intake, genes, demographics, and lifestyle have been identified as being important determinants of vitamin D status, the impact of these factors is expected to differ across populations. To improve current prevention and treatment strategies, this study aimed to explore the main determinants of vitamin D status and its relative importance in a population of community-dwelling Dutch older adults. Methods/subjects Serum 25-hydroxyvitamin D (25(OH)D) was measured in 2857 adults aged =65 years. Sun exposure was assessed with a structured questionnaire (n = 1012), vitamin D intake using a Food Frequency Questionnaire (n = 596), and data on genetic variation that may affect 25(OH)D status was obtained for 4 genes, DHCR7 (rs12785878), CYP2R1 (rs10741657), GC (rs2282679), and CYP24A1 (rs6013897) (n = 2530). Results Serum 25(OH)D concentrations

KW - Serum 25-hydroxyvitamin D

KW - Sunlight

KW - Vitamin D intake

KW - Vitamin D related genetic variation

KW - Vitamin D supplement

U2 - 10.1016/j.jsbmb.2015.08.008

DO - 10.1016/j.jsbmb.2015.08.008

M3 - Article

SN - 0960-0760

VL - 164

SP - 168

EP - 176

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

ER -

Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study

Abstract

Keywords

UN SDGs

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Projects

Vitamine B12 en botontkalking bij ouderen (KB-15-004-003, KB-05-001-021)

Cite this