Relationship between milk fatty acid composition and the expression of lipogenic genes in the mammary gland of dairy cows

N. Mach Casellas; R.M.A. Goselink; J. van Baal; L. Kruijt; A.M. van Vuuren; M.A. Smits

doi:10.1016/j.livsci.2012.10.014

Relationship between milk fatty acid composition and the expression of lipogenic genes in the mammary gland of dairy cows

N. Mach Casellas, R.M.A. Goselink, J. van Baal, L. Kruijt, A.M. van Vuuren, M.A. Smits

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

This study focussed on the complex regulation of lipid metabolism in the mammary gland of cows and the association between milk fatty acid (FA) profile and the expression of lipogenic genes in individual cows. Changes in FA profile were found to be accompanied by changes in the expression of regulatory genes related to a wide range of metabolic functions. Expression of most of key lipogenic genes and transcription factors such as peroxisome proliferator-activated receptor gamma (PPARG), and sterol regulatory element binding factor 1 (SREBP1) was mainly negatively correlated to the concentration of trans-FA and CLA isomers in milk. These correlations suggest that changes in ruminal lipid metabolism may result in modifications in the expression of lipid metabolism-related genes at mammary level.

Original language	English
Pages (from-to)	92-96
Journal	Livestock Science
Volume	151
Issue number	1
DOIs	https://doi.org/10.1016/j.livsci.2012.10.014
Publication status	Published - 2013

Keywords

stearoyl-coa desaturase
nutritional regulation
lipid supplements
lactating cows
tissue
networks
protein

Access to Document

10.1016/j.livsci.2012.10.014

1 Finished

Gezonde vetzuursamenstelling in melk (KB-15-001-006, KB-05-003-047)
van Vuuren, A.
1/01/10 → 31/12/13
Project: EZproject

Cite this

@article{07016112eb9e49898effeab137293627,

title = "Relationship between milk fatty acid composition and the expression of lipogenic genes in the mammary gland of dairy cows",

abstract = "This study focussed on the complex regulation of lipid metabolism in the mammary gland of cows and the association between milk fatty acid (FA) profile and the expression of lipogenic genes in individual cows. Changes in FA profile were found to be accompanied by changes in the expression of regulatory genes related to a wide range of metabolic functions. Expression of most of key lipogenic genes and transcription factors such as peroxisome proliferator-activated receptor gamma (PPARG), and sterol regulatory element binding factor 1 (SREBP1) was mainly negatively correlated to the concentration of trans-FA and CLA isomers in milk. These correlations suggest that changes in ruminal lipid metabolism may result in modifications in the expression of lipid metabolism-related genes at mammary level.",

keywords = "stearoyl-coa desaturase, nutritional regulation, lipid supplements, lactating cows, tissue, networks, protein",

author = "{Mach Casellas}, N. and R.M.A. Goselink and {van Baal}, J. and L. Kruijt and {van Vuuren}, A.M. and M.A. Smits",

year = "2013",

doi = "10.1016/j.livsci.2012.10.014",

language = "English",

volume = "151",

pages = "92--96",

journal = "Livestock Science",

issn = "1871-1413",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Relationship between milk fatty acid composition and the expression of lipogenic genes in the mammary gland of dairy cows

AU - Mach Casellas, N.

AU - Goselink, R.M.A.

AU - van Baal, J.

AU - Kruijt, L.

AU - van Vuuren, A.M.

AU - Smits, M.A.

PY - 2013

Y1 - 2013

N2 - This study focussed on the complex regulation of lipid metabolism in the mammary gland of cows and the association between milk fatty acid (FA) profile and the expression of lipogenic genes in individual cows. Changes in FA profile were found to be accompanied by changes in the expression of regulatory genes related to a wide range of metabolic functions. Expression of most of key lipogenic genes and transcription factors such as peroxisome proliferator-activated receptor gamma (PPARG), and sterol regulatory element binding factor 1 (SREBP1) was mainly negatively correlated to the concentration of trans-FA and CLA isomers in milk. These correlations suggest that changes in ruminal lipid metabolism may result in modifications in the expression of lipid metabolism-related genes at mammary level.

AB - This study focussed on the complex regulation of lipid metabolism in the mammary gland of cows and the association between milk fatty acid (FA) profile and the expression of lipogenic genes in individual cows. Changes in FA profile were found to be accompanied by changes in the expression of regulatory genes related to a wide range of metabolic functions. Expression of most of key lipogenic genes and transcription factors such as peroxisome proliferator-activated receptor gamma (PPARG), and sterol regulatory element binding factor 1 (SREBP1) was mainly negatively correlated to the concentration of trans-FA and CLA isomers in milk. These correlations suggest that changes in ruminal lipid metabolism may result in modifications in the expression of lipid metabolism-related genes at mammary level.

KW - stearoyl-coa desaturase

KW - nutritional regulation

KW - lipid supplements

KW - lactating cows

KW - tissue

KW - networks

KW - protein

U2 - 10.1016/j.livsci.2012.10.014

DO - 10.1016/j.livsci.2012.10.014

M3 - Article

VL - 151

SP - 92

EP - 96

JO - Livestock Science

JF - Livestock Science

SN - 1871-1413

IS - 1

ER -

Relationship between milk fatty acid composition and the expression of lipogenic genes in the mammary gland of dairy cows

Abstract

Keywords

Access to Document

Fingerprint

Projects

Gezonde vetzuursamenstelling in melk (KB-15-001-006, KB-05-003-047)

Cite this