Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population

I.E.J. Milder; A. Kuijsten; I.C.W. Arts; E.J.M. Feskens; E. Kampman; P.C.H. Hollman; P. van 't Veer

doi:10.1093/jn/137.5.1266

Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population

I.E.J. Milder, A. Kuijsten, I.C.W. Arts, E.J.M. Feskens, E. Kampman, P.C.H. Hollman, P. van 't Veer

Nutrition and Disease

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Abstract

Enterolignans are phytoestrogenic compounds derived from the conversion of dietary lignans by the intestinal microflora that may be protective against cardiovascular diseases and cancer. To evaluate the use of enterolignans as biomarkers of dietary lignan intake, we studied the relation between plasma and dietary lignans. We determined the dietary intake of 4 lignans (secoisolariciresinol (SECO), matairesinol (MAT), pinoresinol, and lariciresinol) using the European Prospective Investigation into Cancer and Nutrition FFQ, and plasma enterodiol (END) and enterolactone (ENL) concentrations were determined by liquid chromatography-tandem mass spectrometry. The population consisted of 637 men and women, aged 19-75 y, participating in a case-control study on colorectal adenomas. Participants did not use antibiotics in the preceding calendar year. We found a modest association between lignan intake and plasma END (Spearman r = 0.09, P = 0.03) and ENL (Spearman r = 0.18, P

Original language	English
Pages (from-to)	1266-1271
Journal	The Journal of Nutrition
Volume	137
Issue number	5
DOIs	https://doi.org/10.1093/jn/137.5.1266
Publication status	Published - May 2007

Keywords

food frequency questionnaire
human intestinal bacteria
tandem mass-spectrometry
serum enterolactone
mammalian lignans
plant lignans
secoisolariciresinol diglucoside
liquid-chromatography
phytoestrogens
metabolism

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@article{17daafabca5649b8acd43fbe712f54b6,

title = "Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population",

abstract = "Enterolignans are phytoestrogenic compounds derived from the conversion of dietary lignans by the intestinal microflora that may be protective against cardiovascular diseases and cancer. To evaluate the use of enterolignans as biomarkers of dietary lignan intake, we studied the relation between plasma and dietary lignans. We determined the dietary intake of 4 lignans (secoisolariciresinol (SECO), matairesinol (MAT), pinoresinol, and lariciresinol) using the European Prospective Investigation into Cancer and Nutrition FFQ, and plasma enterodiol (END) and enterolactone (ENL) concentrations were determined by liquid chromatography-tandem mass spectrometry. The population consisted of 637 men and women, aged 19-75 y, participating in a case-control study on colorectal adenomas. Participants did not use antibiotics in the preceding calendar year. We found a modest association between lignan intake and plasma END (Spearman r = 0.09, P = 0.03) and ENL (Spearman r = 0.18, P",

keywords = "food frequency questionnaire, human intestinal bacteria, tandem mass-spectrometry, serum enterolactone, mammalian lignans, plant lignans, secoisolariciresinol diglucoside, liquid-chromatography, phytoestrogens, metabolism",

author = "I.E.J. Milder and A. Kuijsten and I.C.W. Arts and E.J.M. Feskens and E. Kampman and P.C.H. Hollman and {van 't Veer}, P.",

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Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population. / Milder, I.E.J.; Kuijsten, A.; Arts, I.C.W.; Feskens, E.J.M.; Kampman, E.; Hollman, P.C.H.; van 't Veer, P.

In: The Journal of Nutrition, Vol. 137, No. 5, 05.2007, p. 1266-1271.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Milder, I.E.J.

AU - Kuijsten, A.

AU - Arts, I.C.W.

AU - Feskens, E.J.M.

AU - Kampman, E.

AU - Hollman, P.C.H.

AU - van 't Veer, P.

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N2 - Enterolignans are phytoestrogenic compounds derived from the conversion of dietary lignans by the intestinal microflora that may be protective against cardiovascular diseases and cancer. To evaluate the use of enterolignans as biomarkers of dietary lignan intake, we studied the relation between plasma and dietary lignans. We determined the dietary intake of 4 lignans (secoisolariciresinol (SECO), matairesinol (MAT), pinoresinol, and lariciresinol) using the European Prospective Investigation into Cancer and Nutrition FFQ, and plasma enterodiol (END) and enterolactone (ENL) concentrations were determined by liquid chromatography-tandem mass spectrometry. The population consisted of 637 men and women, aged 19-75 y, participating in a case-control study on colorectal adenomas. Participants did not use antibiotics in the preceding calendar year. We found a modest association between lignan intake and plasma END (Spearman r = 0.09, P = 0.03) and ENL (Spearman r = 0.18, P

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KW - plant lignans

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KW - liquid-chromatography

KW - phytoestrogens

KW - metabolism

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