Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population

I.E.J. Milder; A. Kuijsten; I.C.W. Arts; E.J.M. Feskens; E. Kampman; P.C.H. Hollman; P. van 't Veer

doi:10.1093/jn/137.5.1266

Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population

I.E.J. Milder, A. Kuijsten, I.C.W. Arts, E.J.M. Feskens, E. Kampman, P.C.H. Hollman, P. van 't Veer

Nutrition and Disease

Research output: Contribution to journal › Article › Academic › peer-review

54 Citations (Scopus)

Abstract

Enterolignans are phytoestrogenic compounds derived from the conversion of dietary lignans by the intestinal microflora that may be protective against cardiovascular diseases and cancer. To evaluate the use of enterolignans as biomarkers of dietary lignan intake, we studied the relation between plasma and dietary lignans. We determined the dietary intake of 4 lignans (secoisolariciresinol (SECO), matairesinol (MAT), pinoresinol, and lariciresinol) using the European Prospective Investigation into Cancer and Nutrition FFQ, and plasma enterodiol (END) and enterolactone (ENL) concentrations were determined by liquid chromatography-tandem mass spectrometry. The population consisted of 637 men and women, aged 19-75 y, participating in a case-control study on colorectal adenomas. Participants did not use antibiotics in the preceding calendar year. We found a modest association between lignan intake and plasma END (Spearman r = 0.09, P = 0.03) and ENL (Spearman r = 0.18, P

Original language	English
Pages (from-to)	1266-1271
Journal	The Journal of Nutrition
Volume	137
Issue number	5
DOIs	https://doi.org/10.1093/jn/137.5.1266
Publication status	Published - May 2007

Keywords

food frequency questionnaire
human intestinal bacteria
tandem mass-spectrometry
serum enterolactone
mammalian lignans
plant lignans
secoisolariciresinol diglucoside
liquid-chromatography
phytoestrogens
metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jn/137.5.1266

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title = "Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population",

abstract = "Enterolignans are phytoestrogenic compounds derived from the conversion of dietary lignans by the intestinal microflora that may be protective against cardiovascular diseases and cancer. To evaluate the use of enterolignans as biomarkers of dietary lignan intake, we studied the relation between plasma and dietary lignans. We determined the dietary intake of 4 lignans (secoisolariciresinol (SECO), matairesinol (MAT), pinoresinol, and lariciresinol) using the European Prospective Investigation into Cancer and Nutrition FFQ, and plasma enterodiol (END) and enterolactone (ENL) concentrations were determined by liquid chromatography-tandem mass spectrometry. The population consisted of 637 men and women, aged 19-75 y, participating in a case-control study on colorectal adenomas. Participants did not use antibiotics in the preceding calendar year. We found a modest association between lignan intake and plasma END (Spearman r = 0.09, P = 0.03) and ENL (Spearman r = 0.18, P",

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author = "I.E.J. Milder and A. Kuijsten and I.C.W. Arts and E.J.M. Feskens and E. Kampman and P.C.H. Hollman and {van 't Veer}, P.",

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AU - Milder, I.E.J.

AU - Kuijsten, A.

AU - Arts, I.C.W.

AU - Feskens, E.J.M.

AU - Kampman, E.

AU - Hollman, P.C.H.

AU - van 't Veer, P.

PY - 2007/5

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N2 - Enterolignans are phytoestrogenic compounds derived from the conversion of dietary lignans by the intestinal microflora that may be protective against cardiovascular diseases and cancer. To evaluate the use of enterolignans as biomarkers of dietary lignan intake, we studied the relation between plasma and dietary lignans. We determined the dietary intake of 4 lignans (secoisolariciresinol (SECO), matairesinol (MAT), pinoresinol, and lariciresinol) using the European Prospective Investigation into Cancer and Nutrition FFQ, and plasma enterodiol (END) and enterolactone (ENL) concentrations were determined by liquid chromatography-tandem mass spectrometry. The population consisted of 637 men and women, aged 19-75 y, participating in a case-control study on colorectal adenomas. Participants did not use antibiotics in the preceding calendar year. We found a modest association between lignan intake and plasma END (Spearman r = 0.09, P = 0.03) and ENL (Spearman r = 0.18, P

AB - Enterolignans are phytoestrogenic compounds derived from the conversion of dietary lignans by the intestinal microflora that may be protective against cardiovascular diseases and cancer. To evaluate the use of enterolignans as biomarkers of dietary lignan intake, we studied the relation between plasma and dietary lignans. We determined the dietary intake of 4 lignans (secoisolariciresinol (SECO), matairesinol (MAT), pinoresinol, and lariciresinol) using the European Prospective Investigation into Cancer and Nutrition FFQ, and plasma enterodiol (END) and enterolactone (ENL) concentrations were determined by liquid chromatography-tandem mass spectrometry. The population consisted of 637 men and women, aged 19-75 y, participating in a case-control study on colorectal adenomas. Participants did not use antibiotics in the preceding calendar year. We found a modest association between lignan intake and plasma END (Spearman r = 0.09, P = 0.03) and ENL (Spearman r = 0.18, P

KW - food frequency questionnaire

KW - human intestinal bacteria

KW - tandem mass-spectrometry

KW - serum enterolactone

KW - mammalian lignans

KW - plant lignans

KW - secoisolariciresinol diglucoside

KW - liquid-chromatography

KW - phytoestrogens

KW - metabolism

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DO - 10.1093/jn/137.5.1266

M3 - Article

SN - 0022-3166

VL - 137

SP - 1266

EP - 1271

JO - The Journal of Nutrition

JF - The Journal of Nutrition

IS - 5

ER -

Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population

Abstract

Keywords

UN SDGs

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