Abstract
Enterolignans are phytoestrogenic compounds derived from the conversion of dietary lignans by the intestinal microflora that may be protective against cardiovascular diseases and cancer. To evaluate the use of enterolignans as biomarkers of dietary lignan intake, we studied the relation between plasma and dietary lignans. We determined the dietary intake of 4 lignans (secoisolariciresinol (SECO), matairesinol (MAT), pinoresinol, and lariciresinol) using the European Prospective Investigation into Cancer and Nutrition FFQ, and plasma enterodiol (END) and enterolactone (ENL) concentrations were determined by liquid chromatography-tandem mass spectrometry. The population consisted of 637 men and women, aged 19-75 y, participating in a case-control study on colorectal adenomas. Participants did not use antibiotics in the preceding calendar year. We found a modest association between lignan intake and plasma END (Spearman r = 0.09, P = 0.03) and ENL (Spearman r = 0.18, P
Original language | English |
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Pages (from-to) | 1266-1271 |
Journal | The Journal of Nutrition |
Volume | 137 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2007 |
Keywords
- food frequency questionnaire
- human intestinal bacteria
- tandem mass-spectrometry
- serum enterolactone
- mammalian lignans
- plant lignans
- secoisolariciresinol diglucoside
- liquid-chromatography
- phytoestrogens
- metabolism