Projects per year
Abstract
Tuberculosis remains one of the deadliest diseases. Emergence of drug-resistant and multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly challenging. In order to develop novel intervention strategies, detailed understanding of the molecular mechanisms behind the success of this pathogen is required. Here, we review recent literature to provide a systems level overview of the molecular and cellular components involved in divalent metal homeostasis and their role in regulating the three main virulence strategies of M. tuberculosis: immune modulation, dormancy and phagosomal rupture. We provide a visual and modular overview of these components and their regulation. Our analysis identified a single regulatory cascade for these three virulence strategies that respond to limited availability of divalent metals in the phagosome.
Original language | English |
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Article number | 347 |
Journal | International Journal of Molecular Sciences |
Volume | 19 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2018 |
Keywords
- CAMP
- Divalent metal
- Dormancy
- Escape
- Esx
- Immune modulation
- Iron
- Manganese
- Mycobacteria
- Phagosome rupture
- Pore
- Virulence
- Zinc
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Dive into the research topics of 'Regulation of three virulence strategies of Mycobacterium tuberculosis: A success story'. Together they form a unique fingerprint.Projects
- 2 Finished
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MycoSynVac: Engineering of Mycoplasma pneumoniae as a broad-spectrum animal vaccine
1/04/15 → 31/03/20
Project: EU research project
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INFECT: Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures that Dictate Severity of Tissue Infection
1/01/13 → 30/06/18
Project: EU research project