Regulation of three virulence strategies of Mycobacterium tuberculosis: A success story

Niels A. Zondervan, Jesse C.J. Van Dam, Peter J. Schaap, Vitor A.P. Martins dos Santos, Maria Suarez-Diez*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Tuberculosis remains one of the deadliest diseases. Emergence of drug-resistant and multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly challenging. In order to develop novel intervention strategies, detailed understanding of the molecular mechanisms behind the success of this pathogen is required. Here, we review recent literature to provide a systems level overview of the molecular and cellular components involved in divalent metal homeostasis and their role in regulating the three main virulence strategies of M. tuberculosis: immune modulation, dormancy and phagosomal rupture. We provide a visual and modular overview of these components and their regulation. Our analysis identified a single regulatory cascade for these three virulence strategies that respond to limited availability of divalent metals in the phagosome.
Original languageEnglish
Article number347
JournalInternational Journal of Molecular Sciences
Volume19
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • CAMP
  • Divalent metal
  • Dormancy
  • Escape
  • Esx
  • Immune modulation
  • Iron
  • Manganese
  • Mycobacteria
  • Phagosome rupture
  • Pore
  • Virulence
  • Zinc

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