Regulation of the stress response in early vertebrates

M.O. Huising, J.R. Metz, A.F. de Mazon, B.M.L. Verburg-van Kemenade, G. Flik

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)


The acute stress response is a key regulatory system for the maintenance of homeostatic equilibrium that is activated upon an imminent or ongoing disturbance of the "milieu intérieur". In general, the stress response in bony fish is similar to that of mammals. The recent cloning and characterization of corticotropin-releasing hormone-binding protein (CRH-BP) in carp (Cyprinus carpio L.) reflects the conservation of the CRH signaling system throughout vertebrates. Now, we can start to investigate the processes that are mediated by the factors that make up this system. The stress response is only one of these processes.
Original languageEnglish
Pages (from-to)345-347
Number of pages15
JournalAnnals of the New York Academy Of Sciences
Publication statusPublished - 2005


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