Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle

Sharon Rose Hill*, Tanvi Taparia, Rickard Ignell

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: In the light of dengue being the fastest growing transmissible disease, there is a dire need to identify the mechanisms regulating the behaviour of the main vector Aedes aegypti. Disease transmission requires the female mosquito to acquire the pathogen from a blood meal during one gonotrophic cycle, and to pass it on in the next, and the capacity of the vector to maintain the disease relies on a sustained mosquito population. Results: Using a comprehensive transcriptomic approach, we provide insight into the regulation of the odour-mediated host- and oviposition-seeking behaviours throughout the first gonotrophic cycle. We provide clear evidence that the age and state of the female affects antennal transcription differentially. Notably, the temporal- and state-dependent patterns of differential transcript abundance of chemosensory and neuromodulatory genes extends across families, and appears to be linked to concerted differential modulation by subsets of transcription factors. Conclusions: By identifying these regulatory pathways, we provide a substrate for future studies targeting subsets of genes across disparate families involved in generating key vector behaviours, with the goal to develop novel vector control tools.

Original languageEnglish
Article number71
JournalBMC Genomics
Volume22
Issue number1
DOIs
Publication statusPublished - 21 Jan 2021

Keywords

  • Chemosensory-related genes
  • Mosquito, Olfaction
  • Neuromodulatory genes
  • Ontogeny
  • Transcription factors

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