Regulation of Nutrient Metabolism and Inflammation

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

Metabolic and immune-related pathways intersect at numerous levels. Their common regulation is effectuated by several hormonal signaling routes that involve specific nuclear hormone receptors and adipokines. Glucocorticoids and leptin are hormones that play a key role in coordinating energy metabolism and food-seeking behavior during energy deficiency as does the nuclear hormone receptor Peroxisome Proliferator Activated Receptor a (PPARa). Importantly, the glucocorticoid, leptin, and PPARa signaling routes share a profound role in governing inflammation and other immune-related processes. Using specific examples, this chapter aims at illustrating the interplay between metabolism and immunity/inflammation by discussing common endocrine and transcriptional regulators of metabolism and inflammation and by highlighting the interaction between macrophages and metabolically active cells in liver and adipose tissue. Convergence of metabolic and immune signaling is likely at least partially driven by the evolutionary need during times of food insufficiency to minimize loss of energy to processes that are temporarily nonessential to the survival of the species
Original languageEnglish
Title of host publicationSensory and Metabolic Control of Energy Balance, Results and Problems in Cell Differentiation. Volume 52
EditorsW. Meyerhof, U. Beisiegel, H.G. Joost
Place of PublicationBerlin-Heidelberg
Pages13-25
Number of pages205
DOIs
Publication statusPublished - 2010

Publication series

NameResults and Problems in Cell Differentiation
PublisherSpringer-Verlag
Number52

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