Regulation of Lipoprotein Lipase by Angptl4

W. Dijk, A.H. Kersten

Research output: Contribution to journalArticleAcademicpeer-review

88 Citations (Scopus)

Abstract

Triglyceride (TG)-rich chylomicrons and very low density lipoproteins (VLDL) distribute fatty acids (FA) to various tissues by interacting with the enzyme lipoprotein lipase (LPL). The protein angiopoietin-like 4 (Angptl4) is under sensitive transcriptional control by FA and the FA-activated peroxisome proliferator activated receptors (PPARs), and its tissue expression largely overlaps with that of LPL. Growing evidence indicates that Angptl4 mediates the physiological fluctuations in LPL activity, including the decrease in adipose tissue LPL activity during fasting. This review focuses on the major ambiguities concerning the mechanism of LPL inhibition by Angptl4, as well as on the physiological role of Angptl4 in lipid metabolism, highlighting its function in a variety of tissues, and uses this information to make suggestions for further research.
Original languageEnglish
Pages (from-to)146-155
JournalTrends in Endocrinology & Metabolism
Volume25
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • angiopoietin-like protein
  • 4/fasting-induced adipose factor
  • tissue-specific regulation
  • activated receptor-gamma
  • high-density-lipoprotein
  • human skeletal-muscle
  • diet-induced obesity
  • coiled-coil domain
  • fatty-acid uptake
  • triglyceride-metabolism

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