Regulation of lipid metabolism via angiopoietin-like proteins

Research output: Contribution to journalArticleAcademicpeer-review

96 Citations (Scopus)

Abstract

Regulation of mammalian energy metabolism is an intricate process involving numerous hormones, transcription factors and signal transduction cascades. Much of the regulation occurs via secreted factors that relay information from one organ to another. One group of secreted factors that recently emerged as having a major impact on lipid and possibly glucose metabolism are the ANGPTLs (angiopoietin-like proteins). This includes ANGPTL3, ANGPTL4/FIAF (fasting-induced adipose factor), and ANGPTL6/AGF (angiopoietin-related growth factor). Although the receptors for these proteins have yet to be identified, it is nevertheless increasingly clear that these proteins have important effects on plasma triacylglycerol clearance, adipose tissue lipolysis, and adiposity. This review summarizes contemporary data on ANGPTLs with emphasis on the connection with energy metabolism
Original languageEnglish
Pages (from-to)1059-1062
JournalBiochemical Society Transactions
Volume33
Issue number5
DOIs
Publication statusPublished - 2005

Keywords

  • lipoprotein-lipase
  • target gene
  • in-vivo
  • receptor
  • expression
  • mice
  • angiogenesis
  • inhibition
  • angptl3
  • hyperlipidemia

Fingerprint Dive into the research topics of 'Regulation of lipid metabolism via angiopoietin-like proteins'. Together they form a unique fingerprint.

  • Cite this