Regulating gene expression: surprises still in store

R.C. Jansen, J.P.H. Nap

    Research output: Contribution to journalArticleAcademicpeer-review

    21 Citations (Scopus)


    Understanding how genes constitute and contribute to the regulatory networks that result in phenotypic diversity is the major challenge of the post-genome era. Recently, it has been shown that major players in gene regulation can be identified by genome-wide linkage analysis of whole-genome gene expression profiles that were obtained in segregants from yeast strains. Surprisingly, these important elements in regulatory variation are dispersed across several gene ontology classes. Therefore, the regulatory role of transcription factors seems less than was previously anticipated
    Original languageEnglish
    Pages (from-to)223-225
    JournalTrends in Genetics
    Issue number5
    Publication statusPublished - 2004

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