TY - JOUR
T1 - Redox Homeostasis and Mitochondrial Dynamics
AU - Willems, Peter H.G.M.
AU - Rossignol, Rodrigue
AU - Dieteren, Cindy E.J.
AU - Murphy, Michael P.
AU - Koopman, Werner J.H.
PY - 2015/8/4
Y1 - 2015/8/4
N2 - Within living cells, mitochondria are considered relevant sources of reactive oxygen species (ROS) and are exposed to reactive nitrogen species (RNS). During the last decade, accumulating evidence suggests that mitochondrial (dys)function, ROS/RNS levels, and aberrations in mitochondrial morphology are interconnected, albeit in a cell- and context-dependent manner. Here it is hypothesized that ROS and RNS are involved in the short-term regulation of mitochondrial morphology and function via non-transcriptional pathways. We review the evidence for such a mechanism and propose that it allows homeostatic control of mitochondrial function and morphology by redox signaling.
AB - Within living cells, mitochondria are considered relevant sources of reactive oxygen species (ROS) and are exposed to reactive nitrogen species (RNS). During the last decade, accumulating evidence suggests that mitochondrial (dys)function, ROS/RNS levels, and aberrations in mitochondrial morphology are interconnected, albeit in a cell- and context-dependent manner. Here it is hypothesized that ROS and RNS are involved in the short-term regulation of mitochondrial morphology and function via non-transcriptional pathways. We review the evidence for such a mechanism and propose that it allows homeostatic control of mitochondrial function and morphology by redox signaling.
U2 - 10.1016/j.cmet.2015.06.006
DO - 10.1016/j.cmet.2015.06.006
M3 - Article
C2 - 26166745
AN - SCOPUS:84938751663
SN - 1550-4131
VL - 22
SP - 207
EP - 218
JO - Cell Metabolism
JF - Cell Metabolism
IS - 2
ER -