Red and processed meat intake and risk of colorectal adenomas: a systematic review and meta-analysis of epidemiological studies

D. Aune, D.S.M. Chan, A. Vieira, D. Navarro Rosenblatt, R. Vieira, D.C. Greenwood, E. Kampman, T. Norat

Research output: Contribution to journalArticleAcademicpeer-review

96 Citations (Scopus)

Abstract

Background Current evidence indicates that red and processed meat intake increases the risk of colorectal cancer; however, the association with colorectal adenomas is unclear. Objective To conduct a systematic review and meta-analysis of epidemiological studies of red and processed meat intake and risk of colorectal adenomas as part of the Continuous Update Project of the World Cancer Research Fund. Design PubMed and several other databases were searched for relevant studies from their inception up to 31 December 2011. Summary relative risks (RRs) were estimated using a random effects model. Results Nineteen case–control studies and seven prospective studies were included in the analyses. The summary RR per 100 g/day of red meat was 1.27 (95 % CI 1.16–1.40, I2 = 5 %, n = 16) for all studies combined, 1.20 (95 % CI 1.06–1.36, I2 = 0 %, n = 6) for prospective studies, and 1.34 (95 % CI 1.12–1.59, I2 = 31 %, n = 10) for case–control studies. The summary RR per 50 g/day of processed meat intake was 1.29 (95 % CI 1.10–1.53, I2 = 27 %, n = 10) for all studies combined, 1.45 (95 % CI 1.10–1.90, I2 = 0 %, n = 2) for prospective studies, and 1.23 (95 % CI 0.99–1.52, I2 = 37 %, n = 8) for case–control studies. There was evidence of a nonlinear association between red meat (pnonlinearity <0.001) and processed meat (pnonlinearity = 0.01) intake and colorectal adenoma risk. Conclusion These results indicate an elevated risk of colorectal adenomas with intake of red and processed meat, but further prospective studies are warranted
Original languageEnglish
Pages (from-to)611-627
JournalCancer Causes and Control
Volume24
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • dose-response metaanalysis
  • heterocyclic amines
  • dietary factors
  • life-style
  • hyperplastic polyps
  • carcinoma sequence
  • cigarette-smoking
  • burgundy france
  • dairy-products
  • sigmoid colon

Fingerprint Dive into the research topics of 'Red and processed meat intake and risk of colorectal adenomas: a systematic review and meta-analysis of epidemiological studies'. Together they form a unique fingerprint.

  • Cite this

    Aune, D., Chan, D. S. M., Vieira, A., Navarro Rosenblatt, D., Vieira, R., Greenwood, D. C., ... Norat, T. (2013). Red and processed meat intake and risk of colorectal adenomas: a systematic review and meta-analysis of epidemiological studies. Cancer Causes and Control, 24(4), 611-627. https://doi.org/10.1007/s10552-012-0139-z