Ready for regulatory use: NAMs and NGRA for chemical safety assurance

Paul L. Carmichael; Maria T. Baltazar; Sophie Cable; Stella Cochrane; Matthew Dent; Hequn Li; Alistair Middleton; Iris Muller; Georgia Reynolds; Carl Westmoreland; Andrew White

doi:10.14573/altex.2204281

Ready for regulatory use: NAMs and NGRA for chemical safety assurance

Paul L. Carmichael^*, Maria T. Baltazar, Sophie Cable, Stella Cochrane, Matthew Dent, Hequn Li, Alistair Middleton, Iris Muller, Georgia Reynolds, Carl Westmoreland, Andrew White

^*Corresponding author for this work

Toxicology

Research output: Contribution to journal › Editorial › Academic

2 Citations (Scopus)

Abstract

New approach methodologies (NAMs) that do not use experimental animals are, in certain settings, entirely appropriate for assuring the safety of chemical ingredients, although regulatory adoption has been slow. In this opinion article we discuss how scientific advances that utilize NAMs to certify systemic safety are available now and merit broader acceptance within the framework of next generation risk assessments (NGRA).

Original language	English
Pages (from-to)	359-366
Number of pages	8
Journal	Altex
Volume	39
Issue number	3
DOIs	https://doi.org/10.14573/altex.2204281
Publication status	Published - 20 Jul 2022

Keywords

chemical safety
new approach methodologies (NAMs)
next generation risk assessement (NGRA)
non-animal approaches

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10.14573/altex.2204281Licence: CC BY

https://edepot.wur.nl/575201Licence: CC BY

Cite this

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title = "Ready for regulatory use: NAMs and NGRA for chemical safety assurance",

abstract = "New approach methodologies (NAMs) that do not use experimental animals are, in certain settings, entirely appropriate for assuring the safety of chemical ingredients, although regulatory adoption has been slow. In this opinion article we discuss how scientific advances that utilize NAMs to certify systemic safety are available now and merit broader acceptance within the framework of next generation risk assessments (NGRA).",

keywords = "chemical safety, new approach methodologies (NAMs), next generation risk assessement (NGRA), non-animal approaches",

author = "Carmichael, {Paul L.} and Baltazar, {Maria T.} and Sophie Cable and Stella Cochrane and Matthew Dent and Hequn Li and Alistair Middleton and Iris Muller and Georgia Reynolds and Carl Westmoreland and Andrew White",

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T2 - NAMs and NGRA for chemical safety assurance

AU - Carmichael, Paul L.

AU - Baltazar, Maria T.

AU - Cable, Sophie

AU - Cochrane, Stella

AU - Dent, Matthew

AU - Li, Hequn

AU - Middleton, Alistair

AU - Muller, Iris

AU - Reynolds, Georgia

AU - Westmoreland, Carl

AU - White, Andrew

PY - 2022/7/20

Y1 - 2022/7/20

N2 - New approach methodologies (NAMs) that do not use experimental animals are, in certain settings, entirely appropriate for assuring the safety of chemical ingredients, although regulatory adoption has been slow. In this opinion article we discuss how scientific advances that utilize NAMs to certify systemic safety are available now and merit broader acceptance within the framework of next generation risk assessments (NGRA).

AB - New approach methodologies (NAMs) that do not use experimental animals are, in certain settings, entirely appropriate for assuring the safety of chemical ingredients, although regulatory adoption has been slow. In this opinion article we discuss how scientific advances that utilize NAMs to certify systemic safety are available now and merit broader acceptance within the framework of next generation risk assessments (NGRA).

KW - chemical safety

KW - new approach methodologies (NAMs)

KW - next generation risk assessement (NGRA)

KW - non-animal approaches

U2 - 10.14573/altex.2204281

DO - 10.14573/altex.2204281

M3 - Editorial

C2 - 35796331

AN - SCOPUS:85134950735

VL - 39

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EP - 366

JO - Altex

JF - Altex

SN - 0946-7785

IS - 3

ER -

Ready for regulatory use: NAMs and NGRA for chemical safety assurance

Abstract

Keywords

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