Abstract
Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they can highjack host mitochondria. Bajzikova et al. show that the acquired mitochondrial electron transport is necessary to drive de novo pyrimidine synthesis to overcome cell-cycle arrest. Surprisingly, ATP generation is dispensable for tumorigenesis in this context.
Original language | English |
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Pages (from-to) | 399-416.e10 |
Journal | Cell Metabolism |
Volume | 29 |
Issue number | 2 |
DOIs | |
Publication status | Published - 5 Feb 2019 |
Externally published | Yes |
Keywords
- cancer
- coenzyme Q
- dihydroorotate dehydrogenase
- mitochondria
- OXPHOS
- pyrimidine biosynthesis
- respiration