Rats with scopolamine- or MK-801-induced spatial discrimination deficits in the cone field task: animal models for impaired spatial orientation performance

P.C. Bouger, F.J. van der Staay

    Research output: Contribution to journalArticleAcademicpeer-review

    21 Citations (Scopus)

    Abstract

    Spatial cognition appears to be compromised in elderly and in patients suffering from dementia. These deficits are believed to be modelled, at least partly, by the administration of scopolamine or MK-801 in normal adult animals. In order to establish an animal model suited for the evaluation of putative cognition enhancers, we assessed the effects of scopolamine (0.3, 0.5, 0.7 mg kg-1, i.p.) and MK-801 (0.07, 0.08, 0.09 mg kg-1, s.c.) in rats trained in the cone field. This task allows the simultaneous investigation of working memory (WM), reference memory (RM) and search strategies. Scopolamine and MK-801 reliably induced spatial cognition deficits in the cone field without inducing behavioural side effects. This task appears to be suited for assessing the effects of putative cognition-enhancing compounds on spatial cognition.
    Original languageEnglish
    Pages (from-to)331-346
    JournalEuropean Neuropsychopharmacology
    Volume15
    Issue number3
    DOIs
    Publication statusPublished - 2005

    Keywords

    • radial-arm maze
    • reference memory performance
    • receptor antagonist mk-801
    • long-term potentiation
    • alzheimers-disease
    • elderly adults
    • lewis rats
    • cholinergic hypothesis
    • synaptic plasticity
    • learning deficit

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