Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens

Jan W.M. Van Der Linden, Eveline Snelders, Jan P. Arends, Simon M. Daenen, Willem J.G. Melchers, Paul E. Verweij

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Abstract

We report the use of PCR techniques on a formalin-fixed and paraffin-embedded tissue specimen for direct detection of one dominant azole resistance mechanism in a case of disseminated invasive aspergillosis. Rapid detection of mutations associated with azole resistance directly in tissue significantly reduces diagnostic delay.

Original languageEnglish
Pages (from-to)1478-1480
Number of pages3
JournalJournal of Clinical Microbiology
Volume48
Issue number4
DOIs
Publication statusPublished - Apr 2010
Externally publishedYes

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