Randomized Trial of Probiotics and Calcium on Diarrhea and Respiratory Tract Infections in Indonesian Children

R. Agustina, F.J. Kok, O. van de Rest, U. Fahmida, A. Firmansyah, W. Lukito, E.J.M. Feskens, E.G.H.M. van den Heuvel, R. Albers, I.M.J. Bovee-Oudenhoven

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the effects of calcium and probiotics on the incidence and duration of acute diarrhea and acute respiratory tract infections (ARTIs) in low-socioeconomic communities of Jakarta, Indonesia. METHODS: We conducted a 6-month, double-blind, placebo-controlled study in 494 healthy children aged 1 to 6 years who received low-lactose milk with low calcium content (LC; ~50 mg/day; n = 124), regular calcium content (RC; ~440 mg/day; n = 126), RC with 5.108 colony-forming units per day of Lactobacillus casei CRL431 (casei; n = 120), or RC with 5.108 colony-forming units per day of Lactobacillus reuteri DSM17938 (reuteri; n = 124). Number and duration of diarrhea and ARTIs episodes were primary and secondary outcomes, respectively. RESULTS: Incidence of World Health Organization–defined diarrhea (=3 loose/liquid stools in 24 hours) was not significantly different between RC and LC (relative risk [RR]: 0.99 [95% confidence interval (CI): 0.62–1.58]), between casei and RC (RR: 1.21 [95% CI: 0.76–1.92]), or between reuteri and RC (RR: 0.76 [95% CI: 0.46–1.25]) groups. Incidence of all reported diarrhea (=2 loose/liquid stools in 24 hours) was significantly lower in the reuteri versus RC group (RR: 0.68 [95% CI: 0.46–0.99]). Irrespective of the definition used, reuteri significantly reduced diarrhea incidence in children with lower nutritional status (below-median height-and-weight-for-age z score). None of the interventions affected ARTIs. CONCLUSIONS: RC milk, alone or with L casei, did not reduce diarrhea or ARTIs in Indonesian children. L reuteri may prevent diarrhea, especially in children with lower nutritional status
Original languageEnglish
Pages (from-to)e1155-e1164
JournalPediatrics
Volume129
Issue number5
DOIs
Publication statusPublished - 2012

Fingerprint Dive into the research topics of 'Randomized Trial of Probiotics and Calcium on Diarrhea and Respiratory Tract Infections in Indonesian Children'. Together they form a unique fingerprint.

  • Cite this

    Agustina, R., Kok, F. J., van de Rest, O., Fahmida, U., Firmansyah, A., Lukito, W., Feskens, E. J. M., van den Heuvel, E. G. H. M., Albers, R., & Bovee-Oudenhoven, I. M. J. (2012). Randomized Trial of Probiotics and Calcium on Diarrhea and Respiratory Tract Infections in Indonesian Children. Pediatrics, 129(5), e1155-e1164. https://doi.org/10.1542/peds.2011-1379