Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate 1-3

M. Andersson, W. Theis, M.B. Zimmermann, J.T. Forman, M. Jakel, G.S.M.J.E. Duchateau, L.G.J. Frenken, R.F. Hurrell

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

Background: Random serial sampling is widely used in population pharmacokinetic studies and may have advantages compared with conventional fixed time-point evaluation of iron fortification. Objective: Our objective was to validate random serial sampling to judge the efficacy of iron fortification of a low-fat margarine. Design: We conducted a 32-wk placebo-controlled, double-blind, iron-intervention trial in 18–40-y-old Swiss women (n = 142) with serum ferritin (SF) concentrations
Original languageEnglish
Pages (from-to)1094-1104
JournalAmerican Journal of Clinical Nutrition
Volume92
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • population pharmacokinetics
  • relative bioavailability
  • double-blind
  • transferrin receptor
  • dual fortification
  • whole diet
  • deficiency
  • absorption
  • iodine
  • salt

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